node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFRP1 | TMEM165 | ENSBTAP00000009858 | ENSBTAP00000001671 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | GDT1 family protein. | 0.422 |
ARFRP1 | UNC50 | ENSBTAP00000009858 | ENSBTAP00000073817 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. | Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). | 0.668 |
B4GALT6 | DERL2 | ENSBTAP00000053706 | ENSBTAP00000042889 | Beta-1,4-galactosyltransferase 6. | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.543 |
B4GALT6 | GOSR1 | ENSBTAP00000053706 | ENSBTAP00000006525 | Beta-1,4-galactosyltransferase 6. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.619 |
B4GALT6 | PIGO | ENSBTAP00000053706 | ENSBTAP00000053302 | Beta-1,4-galactosyltransferase 6. | Phosphatidylinositol glycan anchor biosynthesis class O. | 0.619 |
B4GALT6 | PIGZ | ENSBTAP00000053706 | ENSBTAP00000015483 | Beta-1,4-galactosyltransferase 6. | Mannosyltransferase. | 0.718 |
B4GALT6 | SLC35A2 | ENSBTAP00000053706 | ENSBTAP00000003591 | Beta-1,4-galactosyltransferase 6. | UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. | 0.551 |
B4GALT6 | SYVN1 | ENSBTAP00000053706 | ENSBTAP00000006699 | Beta-1,4-galactosyltransferase 6. | Synoviolin 1. | 0.538 |
B4GALT6 | TMEM165 | ENSBTAP00000053706 | ENSBTAP00000001671 | Beta-1,4-galactosyltransferase 6. | GDT1 family protein. | 0.593 |
B4GALT6 | UNC50 | ENSBTAP00000053706 | ENSBTAP00000073817 | Beta-1,4-galactosyltransferase 6. | Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). | 0.648 |
DERL2 | B4GALT6 | ENSBTAP00000042889 | ENSBTAP00000053706 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Beta-1,4-galactosyltransferase 6. | 0.543 |
DERL2 | GOSR1 | ENSBTAP00000042889 | ENSBTAP00000006525 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | 0.602 |
DERL2 | PIGO | ENSBTAP00000042889 | ENSBTAP00000053302 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Phosphatidylinositol glycan anchor biosynthesis class O. | 0.599 |
DERL2 | PIGZ | ENSBTAP00000042889 | ENSBTAP00000015483 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Mannosyltransferase. | 0.701 |
DERL2 | SLC35A2 | ENSBTAP00000042889 | ENSBTAP00000003591 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function. | 0.558 |
DERL2 | SYVN1 | ENSBTAP00000042889 | ENSBTAP00000006699 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Synoviolin 1. | 0.953 |
DERL2 | TMEM165 | ENSBTAP00000042889 | ENSBTAP00000001671 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | GDT1 family protein. | 0.568 |
DERL2 | UNC50 | ENSBTAP00000042889 | ENSBTAP00000073817 | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity). | 0.656 |
GOSR1 | B4GALT6 | ENSBTAP00000006525 | ENSBTAP00000053706 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Beta-1,4-galactosyltransferase 6. | 0.619 |
GOSR1 | DERL2 | ENSBTAP00000006525 | ENSBTAP00000042889 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] | Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. | 0.602 |