node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLNR | BDKRB2 | ENSBTAP00000039331 | ENSBTAP00000060552 | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | Bradykinin receptor B2. | 0.530 |
APLNR | GPR37 | ENSBTAP00000039331 | ENSBTAP00000018241 | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | G protein-coupled receptor 37 (Endothelin receptor type B-like). | 0.542 |
APLNR | GPR37L1 | ENSBTAP00000039331 | ENSBTAP00000019957 | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 37-like 1; G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulat [...] | 0.603 |
APLNR | NPY2R | ENSBTAP00000039331 | ENSBTAP00000022125 | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.523 |
APLNR | OPRL1 | ENSBTAP00000039331 | ENSBTAP00000061716 | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.525 |
APLNR | PSAP | ENSBTAP00000039331 | ENSBTAP00000044260 | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | Prosaposin; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of sp [...] | 0.499 |
BDKRB2 | APLNR | ENSBTAP00000060552 | ENSBTAP00000039331 | Bradykinin receptor B2. | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.530 |
BDKRB2 | GPR37 | ENSBTAP00000060552 | ENSBTAP00000018241 | Bradykinin receptor B2. | G protein-coupled receptor 37 (Endothelin receptor type B-like). | 0.594 |
BDKRB2 | GPR37L1 | ENSBTAP00000060552 | ENSBTAP00000019957 | Bradykinin receptor B2. | G-protein coupled receptor 37-like 1; G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulat [...] | 0.669 |
BDKRB2 | NAV1 | ENSBTAP00000060552 | ENSBTAP00000029223 | Bradykinin receptor B2. | Neuron navigator 1. | 0.411 |
BDKRB2 | NPY2R | ENSBTAP00000060552 | ENSBTAP00000022125 | Bradykinin receptor B2. | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.503 |
BDKRB2 | OPRL1 | ENSBTAP00000060552 | ENSBTAP00000061716 | Bradykinin receptor B2. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.535 |
BDKRB2 | PSAP | ENSBTAP00000060552 | ENSBTAP00000044260 | Bradykinin receptor B2. | Prosaposin; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of sp [...] | 0.499 |
EGFL8 | GPR37L1 | ENSBTAP00000005817 | ENSBTAP00000019957 | EGF like domain multiple 8. | G-protein coupled receptor 37-like 1; G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulat [...] | 0.617 |
EGFL8 | PSAP | ENSBTAP00000005817 | ENSBTAP00000044260 | EGF like domain multiple 8. | Prosaposin; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of sp [...] | 0.511 |
GPR37 | APLNR | ENSBTAP00000018241 | ENSBTAP00000039331 | G protein-coupled receptor 37 (Endothelin receptor type B-like). | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. | 0.542 |
GPR37 | BDKRB2 | ENSBTAP00000018241 | ENSBTAP00000060552 | G protein-coupled receptor 37 (Endothelin receptor type B-like). | Bradykinin receptor B2. | 0.594 |
GPR37 | GPR37L1 | ENSBTAP00000018241 | ENSBTAP00000019957 | G protein-coupled receptor 37 (Endothelin receptor type B-like). | G-protein coupled receptor 37-like 1; G-protein coupled receptor (By similarity). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulat [...] | 0.604 |
GPR37 | NPY2R | ENSBTAP00000018241 | ENSBTAP00000022125 | G protein-coupled receptor 37 (Endothelin receptor type B-like). | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. | 0.540 |
GPR37 | OPRL1 | ENSBTAP00000018241 | ENSBTAP00000061716 | G protein-coupled receptor 37 (Endothelin receptor type B-like). | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.578 |