LIG4 protein (Bos taurus) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

LIG4

DNA ligase. (911 aa)

Predicted Functional Partners:

NHEJ1

0.989

XRCC6

0.985

XRCC5

0.985

PRKDC

0.971

XRCC1

0.967

XRCC4

0.952

DCLRE1C

0.936

PAXX

0.912

RAD52

0.905

ATM

0.886

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	DCLRE1C	ENSBTAP00000039884	ENSBTAP00000013484	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1C.	0.705
ATM	LIG4	ENSBTAP00000039884	ENSBTAP00000021092	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA ligase.	0.886
ATM	NHEJ1	ENSBTAP00000039884	ENSBTAP00000041475	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Non-homologous end joining factor 1.	0.658
ATM	PAXX	ENSBTAP00000039884	ENSBTAP00000069447	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAXX non-homologous end joining factor.	0.621
ATM	PRKDC	ENSBTAP00000039884	ENSBTAP00000022631	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.763
ATM	RAD52	ENSBTAP00000039884	ENSBTAP00000052915	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	RAD52 homolog, DNA repair protein.	0.948
ATM	XRCC1	ENSBTAP00000039884	ENSBTAP00000061591	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 1.	0.853
ATM	XRCC4	ENSBTAP00000039884	ENSBTAP00000040350	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.563
ATM	XRCC5	ENSBTAP00000039884	ENSBTAP00000013758	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 5.	0.910
ATM	XRCC6	ENSBTAP00000039884	ENSBTAP00000008020	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross complementing 6.	0.927
DCLRE1C	ATM	ENSBTAP00000013484	ENSBTAP00000039884	DNA cross-link repair 1C.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.705
DCLRE1C	LIG4	ENSBTAP00000013484	ENSBTAP00000021092	DNA cross-link repair 1C.	DNA ligase.	0.936
DCLRE1C	NHEJ1	ENSBTAP00000013484	ENSBTAP00000041475	DNA cross-link repair 1C.	Non-homologous end joining factor 1.	0.868
DCLRE1C	PAXX	ENSBTAP00000013484	ENSBTAP00000069447	DNA cross-link repair 1C.	PAXX non-homologous end joining factor.	0.536
DCLRE1C	PRKDC	ENSBTAP00000013484	ENSBTAP00000022631	DNA cross-link repair 1C.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.974
DCLRE1C	RAD52	ENSBTAP00000013484	ENSBTAP00000052915	DNA cross-link repair 1C.	RAD52 homolog, DNA repair protein.	0.425
DCLRE1C	XRCC1	ENSBTAP00000013484	ENSBTAP00000061591	DNA cross-link repair 1C.	X-ray repair cross complementing 1.	0.708
DCLRE1C	XRCC4	ENSBTAP00000013484	ENSBTAP00000040350	DNA cross-link repair 1C.	X-ray repair complementing defective repair in Chinese hamster cells 4.	0.679
DCLRE1C	XRCC5	ENSBTAP00000013484	ENSBTAP00000013758	DNA cross-link repair 1C.	X-ray repair cross complementing 5.	0.971
DCLRE1C	XRCC6	ENSBTAP00000013484	ENSBTAP00000008020	DNA cross-link repair 1C.	X-ray repair cross complementing 6.	0.951

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