RHNO1 protein (Bos taurus) - STRING interaction network

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RHNO1

RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity). (241 aa)

Predicted Functional Partners:

TOPBP1

0.939

RAD1

0.921

HUS1

0.914

RAD9A

0.878

BRIP1

0.820

RAD9B

0.781

ATRIP

0.778

PWP1

0.683

C8H9orf85

0.679

DCAF11

0.659

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRIP	BRIP1	ENSBTAP00000048150	ENSBTAP00000053187	ATR interacting protein.	BRCA1 interacting protein C-terminal helicase 1.	0.572
ATRIP	HUS1	ENSBTAP00000048150	ENSBTAP00000017599	ATR interacting protein.	Checkpoint protein; Belongs to the HUS1 family.	0.925
ATRIP	RAD1	ENSBTAP00000048150	ENSBTAP00000025568	ATR interacting protein.	RAD1 checkpoint DNA exonuclease.	0.688
ATRIP	RAD9A	ENSBTAP00000048150	ENSBTAP00000016108	ATR interacting protein.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.696
ATRIP	RAD9B	ENSBTAP00000048150	ENSBTAP00000024392	ATR interacting protein.	Cell cycle checkpoint control protein RAD9B.	0.646
ATRIP	RHNO1	ENSBTAP00000048150	ENSBTAP00000021104	ATR interacting protein.	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).	0.778
ATRIP	TOPBP1	ENSBTAP00000048150	ENSBTAP00000059732	ATR interacting protein.	DNA topoisomerase II binding protein 1.	0.997
BRIP1	ATRIP	ENSBTAP00000053187	ENSBTAP00000048150	BRCA1 interacting protein C-terminal helicase 1.	ATR interacting protein.	0.572
BRIP1	HUS1	ENSBTAP00000053187	ENSBTAP00000017599	BRCA1 interacting protein C-terminal helicase 1.	Checkpoint protein; Belongs to the HUS1 family.	0.555
BRIP1	RAD1	ENSBTAP00000053187	ENSBTAP00000025568	BRCA1 interacting protein C-terminal helicase 1.	RAD1 checkpoint DNA exonuclease.	0.614
BRIP1	RAD9A	ENSBTAP00000053187	ENSBTAP00000016108	BRCA1 interacting protein C-terminal helicase 1.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.621
BRIP1	RAD9B	ENSBTAP00000053187	ENSBTAP00000024392	BRCA1 interacting protein C-terminal helicase 1.	Cell cycle checkpoint control protein RAD9B.	0.569
BRIP1	RHNO1	ENSBTAP00000053187	ENSBTAP00000021104	BRCA1 interacting protein C-terminal helicase 1.	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).	0.820
BRIP1	TOPBP1	ENSBTAP00000053187	ENSBTAP00000059732	BRCA1 interacting protein C-terminal helicase 1.	DNA topoisomerase II binding protein 1.	0.985
C8H9orf85	RHNO1	ENSBTAP00000061346	ENSBTAP00000021104	Uncharacterized protein.	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).	0.679
DCAF11	PWP1	ENSBTAP00000028515	ENSBTAP00000006109	DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity). Belongs to the WD repeat PWP1 family.	0.638
DCAF11	RHNO1	ENSBTAP00000028515	ENSBTAP00000021104	DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation (By similarity).	0.659
HUS1	ATRIP	ENSBTAP00000017599	ENSBTAP00000048150	Checkpoint protein; Belongs to the HUS1 family.	ATR interacting protein.	0.925
HUS1	BRIP1	ENSBTAP00000017599	ENSBTAP00000053187	Checkpoint protein; Belongs to the HUS1 family.	BRCA1 interacting protein C-terminal helicase 1.	0.555
HUS1	RAD1	ENSBTAP00000017599	ENSBTAP00000025568	Checkpoint protein; Belongs to the HUS1 family.	RAD1 checkpoint DNA exonuclease.	0.999

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