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ARSA protein (Bos taurus) - STRING interaction network
"ARSA" - Arylsulfatase A in Bos taurus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ARSAArylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family (507 aa)    
Predicted Functional Partners:
SUMF1
Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also called C(alpha)-formylglycine. Known substrates include GALNS, ARSA, STS and ARSE (By similarity); Belongs to the sulfatase-modifying factor family (374 aa)
 
  0.971
GALNS
Uncharacterized protein; Bos taurus galactosamine (N-acetyl)-6-sulfate sulfatase (GALNS), mRNA (527 aa)
   
 
0.965
CYB5R3
NADH-cytochrome b5 reductase 3; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family (302 aa)
     
 
  0.952
GALC
Galactosylceramidase (685 aa)
         
  0.952
SUMF2
Sulfatase-modifying factor 2; Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1 (By similarity) (301 aa)
 
  0.951
GLA
Galactosidase, alpha (439 aa)
     
  0.943
NPC2
Epididymal secretory protein E1; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding po [...] (149 aa)
         
  0.939
GUSB
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family (652 aa)
     
  0.938
RNASET2
RNASET2 protein; Bos taurus ribonuclease T2 (RNASET2), mRNA; Belongs to the RNase T2 family (291 aa)
     
 
  0.938
ARSB
ARSB protein; Bos taurus arylsulfatase B (ARSB), mRNA (533 aa)
   
   
0.937
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bos taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, domestic cattle, domestic cow
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