| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APC | AXIN1 | ENSBTAP00000057792 | ENSBTAP00000067751 | APC regulator of WNT signaling pathway. | Axin 1. | 0.999 |
| APC | AXIN2 | ENSBTAP00000057792 | ENSBTAP00000040177 | APC regulator of WNT signaling pathway. | Axin 2. | 0.989 |
| APC | CDH1 | ENSBTAP00000057792 | ENSBTAP00000073179 | APC regulator of WNT signaling pathway. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.526 |
| APC | CTNNB1 | ENSBTAP00000057792 | ENSBTAP00000021838 | APC regulator of WNT signaling pathway. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.999 |
| APC | CTNNBIP1 | ENSBTAP00000057792 | ENSBTAP00000068342 | APC regulator of WNT signaling pathway. | Beta-catenin-interacting protein 1; Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. | 0.939 |
| APC | GSK3B | ENSBTAP00000057792 | ENSBTAP00000051604 | APC regulator of WNT signaling pathway. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.998 |
| APC | LEF1 | ENSBTAP00000057792 | ENSBTAP00000061494 | APC regulator of WNT signaling pathway. | Lymphoid enhancer binding factor 1. | 0.972 |
| APC | TCF7 | ENSBTAP00000057792 | ENSBTAP00000001329 | APC regulator of WNT signaling pathway. | Transcription factor 7. | 0.962 |
| APC | TCF7L2 | ENSBTAP00000057792 | ENSBTAP00000065653 | APC regulator of WNT signaling pathway. | Transcription factor 7 like 2. | 0.965 |
| AXIN1 | APC | ENSBTAP00000067751 | ENSBTAP00000057792 | Axin 1. | APC regulator of WNT signaling pathway. | 0.999 |
| AXIN1 | AXIN2 | ENSBTAP00000067751 | ENSBTAP00000040177 | Axin 1. | Axin 2. | 0.997 |
| AXIN1 | CDH1 | ENSBTAP00000067751 | ENSBTAP00000073179 | Axin 1. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.514 |
| AXIN1 | CTNNB1 | ENSBTAP00000067751 | ENSBTAP00000021838 | Axin 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.999 |
| AXIN1 | CTNNBIP1 | ENSBTAP00000067751 | ENSBTAP00000068342 | Axin 1. | Beta-catenin-interacting protein 1; Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. | 0.923 |
| AXIN1 | GSK3B | ENSBTAP00000067751 | ENSBTAP00000051604 | Axin 1. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.999 |
| AXIN1 | LEF1 | ENSBTAP00000067751 | ENSBTAP00000061494 | Axin 1. | Lymphoid enhancer binding factor 1. | 0.981 |
| AXIN1 | TCF7 | ENSBTAP00000067751 | ENSBTAP00000001329 | Axin 1. | Transcription factor 7. | 0.965 |
| AXIN1 | TCF7L2 | ENSBTAP00000067751 | ENSBTAP00000065653 | Axin 1. | Transcription factor 7 like 2. | 0.967 |
| AXIN2 | APC | ENSBTAP00000040177 | ENSBTAP00000057792 | Axin 2. | APC regulator of WNT signaling pathway. | 0.989 |
| AXIN2 | AXIN1 | ENSBTAP00000040177 | ENSBTAP00000067751 | Axin 2. | Axin 1. | 0.997 |
