node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | CYP7A1 | ENSBTAP00000002582 | ENSBTAP00000006957 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.424 |
CYP51A1 | DHCR24 | ENSBTAP00000002582 | ENSBTAP00000069716 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 24-dehydrocholesterol reductase. | 0.994 |
CYP51A1 | DHCR7 | ENSBTAP00000002582 | ENSBTAP00000021892 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family. | 0.975 |
CYP51A1 | HSD17B7 | ENSBTAP00000002582 | ENSBTAP00000007841 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Hydroxysteroid 17-beta dehydrogenase 7. | 0.994 |
CYP51A1 | LSS | ENSBTAP00000002582 | ENSBTAP00000025201 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | 0.999 |
CYP51A1 | MSMO1 | ENSBTAP00000002582 | ENSBTAP00000003991 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. | 0.999 |
CYP51A1 | NSDHL | ENSBTAP00000002582 | ENSBTAP00000012167 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. | 0.989 |
CYP51A1 | SC5D | ENSBTAP00000002582 | ENSBTAP00000072762 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.976 |
CYP51A1 | SOAT1 | ENSBTAP00000002582 | ENSBTAP00000033865 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | O-acyltransferase. | 0.457 |
CYP51A1 | SQLE | ENSBTAP00000002582 | ENSBTAP00000007228 | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | Squalene monooxygenase. | 0.998 |
CYP7A1 | CYP51A1 | ENSBTAP00000006957 | ENSBTAP00000002582 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] | 0.424 |
CYP7A1 | DHCR24 | ENSBTAP00000006957 | ENSBTAP00000069716 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 24-dehydrocholesterol reductase. | 0.897 |
CYP7A1 | DHCR7 | ENSBTAP00000006957 | ENSBTAP00000021892 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family. | 0.929 |
CYP7A1 | HSD17B7 | ENSBTAP00000006957 | ENSBTAP00000007841 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Hydroxysteroid 17-beta dehydrogenase 7. | 0.733 |
CYP7A1 | LSS | ENSBTAP00000006957 | ENSBTAP00000025201 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. | 0.838 |
CYP7A1 | MSMO1 | ENSBTAP00000006957 | ENSBTAP00000003991 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. | 0.864 |
CYP7A1 | NSDHL | ENSBTAP00000006957 | ENSBTAP00000012167 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis. | 0.614 |
CYP7A1 | SC5D | ENSBTAP00000006957 | ENSBTAP00000072762 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Sterol-C5-desaturase; Belongs to the sterol desaturase family. | 0.545 |
CYP7A1 | SOAT1 | ENSBTAP00000006957 | ENSBTAP00000033865 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | O-acyltransferase. | 0.836 |
CYP7A1 | SQLE | ENSBTAP00000006957 | ENSBTAP00000007228 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | Squalene monooxygenase. | 0.636 |