STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. (804 aa)    
Predicted Functional Partners:
CYP3A4
Uncharacterized protein.
 
  
 
 0.947
CYB5B
Cytochrome b5 type B; Belongs to the cytochrome b5 family.
   
 
 0.940
CYB5A
Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
   
 
 0.939
CYP3A5-2
Cytochrome P450, family 3, subfamily A, polypeptide 5.
 
  
 
 0.930
HMOX1
Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
   
 
 0.921
CYP3A24
Uncharacterized protein.
 
  
 
 0.919
CYP4F2-2
Uncharacterized protein; Belongs to the cytochrome P450 family.
 
  
 
 0.910
LOC509506
Uncharacterized protein; Belongs to the cytochrome P450 family.
 
  
 
 0.897
CYP4A22
CYP4A22 protein; Belongs to the cytochrome P450 family.
 
  
 
 0.892
CYP4V2
Uncharacterized protein; Belongs to the cytochrome P450 family.
 
  
 
 0.878
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.