node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | USP12 | ENSBTAP00000030053 | ENSBTAP00000058257 | Androgen receptor. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.693 |
AR | WDR20 | ENSBTAP00000030053 | ENSBTAP00000056668 | Androgen receptor. | WD repeat domain 20. | 0.566 |
AR | WDR48 | ENSBTAP00000030053 | ENSBTAP00000004876 | Androgen receptor. | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. | 0.576 |
DMWD | USP12 | ENSBTAP00000067649 | ENSBTAP00000058257 | DM1 locus, WD repeat containing. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.703 |
DMWD | WDR48 | ENSBTAP00000067649 | ENSBTAP00000004876 | DM1 locus, WD repeat containing. | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. | 0.805 |
FAM228B | TTC22 | ENSBTAP00000041212 | ENSBTAP00000022771 | Protein FAM228B; Belongs to the FAM228 family. | Tetratricopeptide repeat domain 22. | 0.677 |
FAM228B | USP12 | ENSBTAP00000041212 | ENSBTAP00000058257 | Protein FAM228B; Belongs to the FAM228 family. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.657 |
FANCD2 | RAD51AP1 | ENSBTAP00000013299 | ENSBTAP00000012163 | FA complementation group D2. | RAD51 associated protein 1. | 0.468 |
FANCD2 | USP12 | ENSBTAP00000013299 | ENSBTAP00000058257 | FA complementation group D2. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.705 |
FANCD2 | WDR48 | ENSBTAP00000013299 | ENSBTAP00000004876 | FA complementation group D2. | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. | 0.925 |
FANCD2 | ZUP1 | ENSBTAP00000013299 | ENSBTAP00000005061 | FA complementation group D2. | Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Belongs to the peptidase C78 family. ZUFSP subfamily. | 0.451 |
JOSD2 | USP12 | ENSBTAP00000008984 | ENSBTAP00000058257 | Josephin domain containing 2. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.642 |
JOSD2 | WDR20 | ENSBTAP00000008984 | ENSBTAP00000056668 | Josephin domain containing 2. | WD repeat domain 20. | 0.419 |
JOSD2 | ZUP1 | ENSBTAP00000008984 | ENSBTAP00000005061 | Josephin domain containing 2. | Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress. Belongs to the peptidase C78 family. ZUFSP subfamily. | 0.749 |
RAD51AP1 | FANCD2 | ENSBTAP00000012163 | ENSBTAP00000013299 | RAD51 associated protein 1. | FA complementation group D2. | 0.468 |
RAD51AP1 | USP12 | ENSBTAP00000012163 | ENSBTAP00000058257 | RAD51 associated protein 1. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.654 |
RAD51AP1 | WDR48 | ENSBTAP00000012163 | ENSBTAP00000004876 | RAD51 associated protein 1. | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes; Belongs to the WD repeat WDR48 family. | 0.973 |
TTC22 | FAM228B | ENSBTAP00000022771 | ENSBTAP00000041212 | Tetratricopeptide repeat domain 22. | Protein FAM228B; Belongs to the FAM228 family. | 0.677 |
TTC22 | USP12 | ENSBTAP00000022771 | ENSBTAP00000058257 | Tetratricopeptide repeat domain 22. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.659 |
USP12 | AR | ENSBTAP00000058257 | ENSBTAP00000030053 | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | Androgen receptor. | 0.693 |