Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SBSPONSomatomedin-B and thrombospondin type-1 domain-containing protein. (264 aa)    
Predicted Functional Partners:
TRMT9B
Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity).
      
 0.726
POFUT2
Protein O-fucosyltransferase 2.
     
 0.719
SUPT20H
SPT20 homolog, SAGA complex component.
      
 0.693
RSPO4
R-spondin 4.
      
 0.689
KCNK18
Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
      
 0.672
ZNF326
DBIRD complex subunit ZNF326; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro (By similarity).
      
 0.669
DEXI
Dexi homolog.
      
 0.661
TRAPPC13
Trafficking protein particle complex subunit 13.
      
 0.660
RSPO1
R-spondin 1.
      
 0.645
SSPO
SCO-spondin; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system; Belongs to the thrombospondin family.
    
 
 0.631
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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