node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | FGFR1 | ENSBTAP00000070620 | ENSBTAP00000058842 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.451 |
EGFR | FGFR2 | ENSBTAP00000070620 | ENSBTAP00000059738 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.632 |
EGFR | ITK | ENSBTAP00000070620 | ENSBTAP00000034966 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.429 |
EGFR | PDGFRB | ENSBTAP00000070620 | ENSBTAP00000064374 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.977 |
EGFR | PLCG1 | ENSBTAP00000070620 | ENSBTAP00000023383 | Receptor protein-tyrosine kinase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | 0.988 |
EGFR | PRKCA | ENSBTAP00000070620 | ENSBTAP00000001407 | Receptor protein-tyrosine kinase. | Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] | 0.590 |
EGFR | VAV1 | ENSBTAP00000070620 | ENSBTAP00000050922 | Receptor protein-tyrosine kinase. | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.682 |
FGFR1 | EGFR | ENSBTAP00000058842 | ENSBTAP00000070620 | Fibroblast growth factor receptor. | Receptor protein-tyrosine kinase. | 0.451 |
FGFR1 | FGFR2 | ENSBTAP00000058842 | ENSBTAP00000059738 | Fibroblast growth factor receptor. | Fibroblast growth factor receptor. | 0.545 |
FGFR1 | PDGFRB | ENSBTAP00000058842 | ENSBTAP00000064374 | Fibroblast growth factor receptor. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.503 |
FGFR1 | PLCG1 | ENSBTAP00000058842 | ENSBTAP00000023383 | Fibroblast growth factor receptor. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | 0.982 |
FGFR2 | EGFR | ENSBTAP00000059738 | ENSBTAP00000070620 | Fibroblast growth factor receptor. | Receptor protein-tyrosine kinase. | 0.632 |
FGFR2 | FGFR1 | ENSBTAP00000059738 | ENSBTAP00000058842 | Fibroblast growth factor receptor. | Fibroblast growth factor receptor. | 0.545 |
FGFR2 | PLCG1 | ENSBTAP00000059738 | ENSBTAP00000023383 | Fibroblast growth factor receptor. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | 0.977 |
ITK | EGFR | ENSBTAP00000034966 | ENSBTAP00000070620 | Tyrosine-protein kinase. | Receptor protein-tyrosine kinase. | 0.429 |
ITK | LAT | ENSBTAP00000034966 | ENSBTAP00000028315 | Tyrosine-protein kinase. | Linker for activation of T cells. | 0.851 |
ITK | LCP2 | ENSBTAP00000034966 | ENSBTAP00000012345 | Tyrosine-protein kinase. | Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa). | 0.990 |
ITK | PLCG1 | ENSBTAP00000034966 | ENSBTAP00000023383 | Tyrosine-protein kinase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | 0.977 |
ITK | SYK | ENSBTAP00000034966 | ENSBTAP00000070101 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.646 |
ITK | VAV1 | ENSBTAP00000034966 | ENSBTAP00000050922 | Tyrosine-protein kinase. | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.985 |