HGF protein (Bos taurus) - STRING interaction network

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HGF

Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)

Predicted Functional Partners:

MET

0.999

IGF1

0.982

VEGFC

0.959

VEGFD

0.953

EGFR

0.946

PDGFB

0.941

ERBB3

0.938

PDGFA

0.936

PDGFD

0.927

PDGFC

0.924

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB3	ENSBTAP00000070620	ENSBTAP00000013790	Receptor protein-tyrosine kinase.	Erb-b2 receptor tyrosine kinase 3.	0.992
EGFR	HGF	ENSBTAP00000070620	ENSBTAP00000023490	Receptor protein-tyrosine kinase.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	0.946
EGFR	IGF1	ENSBTAP00000070620	ENSBTAP00000055243	Receptor protein-tyrosine kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.975
EGFR	MET	ENSBTAP00000070620	ENSBTAP00000008102	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.822
EGFR	PDGFA	ENSBTAP00000070620	ENSBTAP00000063379	Receptor protein-tyrosine kinase.	Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...]	0.949
EGFR	PDGFB	ENSBTAP00000070620	ENSBTAP00000056346	Receptor protein-tyrosine kinase.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.948
EGFR	PDGFC	ENSBTAP00000070620	ENSBTAP00000053852	Receptor protein-tyrosine kinase.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.951
EGFR	PDGFD	ENSBTAP00000070620	ENSBTAP00000046207	Receptor protein-tyrosine kinase.	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.922
EGFR	VEGFC	ENSBTAP00000070620	ENSBTAP00000019613	Receptor protein-tyrosine kinase.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.794
EGFR	VEGFD	ENSBTAP00000070620	ENSBTAP00000012474	Receptor protein-tyrosine kinase.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.742
ERBB3	EGFR	ENSBTAP00000013790	ENSBTAP00000070620	Erb-b2 receptor tyrosine kinase 3.	Receptor protein-tyrosine kinase.	0.992
ERBB3	HGF	ENSBTAP00000013790	ENSBTAP00000023490	Erb-b2 receptor tyrosine kinase 3.	Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily.	0.938
ERBB3	IGF1	ENSBTAP00000013790	ENSBTAP00000055243	Erb-b2 receptor tyrosine kinase 3.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.805
ERBB3	MET	ENSBTAP00000013790	ENSBTAP00000008102	Erb-b2 receptor tyrosine kinase 3.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.960
ERBB3	PDGFA	ENSBTAP00000013790	ENSBTAP00000063379	Erb-b2 receptor tyrosine kinase 3.	Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...]	0.723
ERBB3	PDGFB	ENSBTAP00000013790	ENSBTAP00000056346	Erb-b2 receptor tyrosine kinase 3.	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family.	0.699
ERBB3	PDGFC	ENSBTAP00000013790	ENSBTAP00000053852	Erb-b2 receptor tyrosine kinase 3.	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.703
ERBB3	PDGFD	ENSBTAP00000013790	ENSBTAP00000046207	Erb-b2 receptor tyrosine kinase 3.	Platelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.707
ERBB3	VEGFC	ENSBTAP00000013790	ENSBTAP00000019613	Erb-b2 receptor tyrosine kinase 3.	Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family.	0.706
ERBB3	VEGFD	ENSBTAP00000013790	ENSBTAP00000012474	Erb-b2 receptor tyrosine kinase 3.	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	0.657

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