node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CA1 | CA2 | ENSBTAP00000043090 | ENSBTAP00000023581 | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | 0.728 |
CA1 | SLC4A1 | ENSBTAP00000043090 | ENSBTAP00000002081 | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. | Anion exchange protein. | 0.514 |
CA2 | CA1 | ENSBTAP00000023581 | ENSBTAP00000043090 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. | 0.728 |
CA2 | CBS | ENSBTAP00000023581 | ENSBTAP00000063539 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.826 |
CA2 | CLCN7 | ENSBTAP00000023581 | ENSBTAP00000021122 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | 0.698 |
CA2 | CTSK | ENSBTAP00000023581 | ENSBTAP00000028016 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | 0.748 |
CA2 | NFATC1 | ENSBTAP00000023581 | ENSBTAP00000000859 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | 0.686 |
CA2 | OSTM1 | ENSBTAP00000023581 | ENSBTAP00000064390 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Osteoclastogenesis associated transmembrane protein 1. | 0.687 |
CA2 | SLC4A1 | ENSBTAP00000023581 | ENSBTAP00000002081 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Anion exchange protein. | 0.847 |
CA2 | SLC4A2 | ENSBTAP00000023581 | ENSBTAP00000063316 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Anion exchange protein. | 0.676 |
CA2 | SLC4A4 | ENSBTAP00000023581 | ENSBTAP00000060761 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family. | 0.808 |
CA2 | SLC9A1 | ENSBTAP00000023581 | ENSBTAP00000048292 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. | 0.886 |
CBS | CA2 | ENSBTAP00000063539 | ENSBTAP00000023581 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | 0.826 |
CLCN7 | CA2 | ENSBTAP00000021122 | ENSBTAP00000023581 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | 0.698 |
CLCN7 | CTSK | ENSBTAP00000021122 | ENSBTAP00000028016 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | 0.757 |
CLCN7 | NFATC1 | ENSBTAP00000021122 | ENSBTAP00000000859 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity). | 0.570 |
CLCN7 | OSTM1 | ENSBTAP00000021122 | ENSBTAP00000064390 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | Osteoclastogenesis associated transmembrane protein 1. | 0.999 |
CLCN7 | SLC4A2 | ENSBTAP00000021122 | ENSBTAP00000063316 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | Anion exchange protein. | 0.703 |
CTSK | CA2 | ENSBTAP00000028016 | ENSBTAP00000023581 | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. | 0.748 |
CTSK | CLCN7 | ENSBTAP00000028016 | ENSBTAP00000021122 | Cathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | 0.757 |