| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD19 | CD4 | ENSBTAP00000008598 | ENSBTAP00000037566 | CD19 molecule. | CD4 molecule. | 0.944 |
| CD19 | CD40 | ENSBTAP00000008598 | ENSBTAP00000027630 | CD19 molecule. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.912 |
| CD19 | CD86 | ENSBTAP00000008598 | ENSBTAP00000071927 | CD19 molecule. | CD86 molecule. | 0.871 |
| CD19 | FAS | ENSBTAP00000008598 | ENSBTAP00000014282 | CD19 molecule. | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). | 0.772 |
| CD19 | FASLG | ENSBTAP00000008598 | ENSBTAP00000043860 | CD19 molecule. | LOC407111 protein; Belongs to the tumor necrosis factor family. | 0.432 |
| CD19 | ICOS | ENSBTAP00000008598 | ENSBTAP00000028775 | CD19 molecule. | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.874 |
| CD19 | IFNG | ENSBTAP00000008598 | ENSBTAP00000016634 | CD19 molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.887 |
| CD19 | IL2 | ENSBTAP00000008598 | ENSBTAP00000027819 | CD19 molecule. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.873 |
| CD19 | IL4 | ENSBTAP00000008598 | ENSBTAP00000021215 | CD19 molecule. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.934 |
| CD19 | LOC112445051 | ENSBTAP00000008598 | ENSBTAP00000023717 | CD19 molecule. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.878 |
| CD4 | CD19 | ENSBTAP00000037566 | ENSBTAP00000008598 | CD4 molecule. | CD19 molecule. | 0.944 |
| CD4 | CD40 | ENSBTAP00000037566 | ENSBTAP00000027630 | CD4 molecule. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.923 |
| CD4 | CD86 | ENSBTAP00000037566 | ENSBTAP00000071927 | CD4 molecule. | CD86 molecule. | 0.952 |
| CD4 | FAS | ENSBTAP00000037566 | ENSBTAP00000014282 | CD4 molecule. | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). | 0.794 |
| CD4 | FASLG | ENSBTAP00000037566 | ENSBTAP00000043860 | CD4 molecule. | LOC407111 protein; Belongs to the tumor necrosis factor family. | 0.720 |
| CD4 | ICOS | ENSBTAP00000037566 | ENSBTAP00000028775 | CD4 molecule. | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin- 2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40- mediated class switching o [...] | 0.929 |
| CD4 | IFNG | ENSBTAP00000037566 | ENSBTAP00000016634 | CD4 molecule. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.965 |
| CD4 | IL2 | ENSBTAP00000037566 | ENSBTAP00000027819 | CD4 molecule. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. | 0.961 |
| CD4 | IL4 | ENSBTAP00000037566 | ENSBTAP00000021215 | CD4 molecule. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.949 |
| CD4 | LOC112445051 | ENSBTAP00000037566 | ENSBTAP00000023717 | CD4 molecule. | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] | 0.933 |
