| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD274 | CD28 | ENSBTAP00000008067 | ENSBTAP00000069428 | Programmed cell death-ligand 1. | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | 0.511 |
| CD274 | CD4 | ENSBTAP00000008067 | ENSBTAP00000037566 | Programmed cell death-ligand 1. | CD4 molecule. | 0.950 |
| CD274 | CD40 | ENSBTAP00000008067 | ENSBTAP00000027630 | Programmed cell death-ligand 1. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.795 |
| CD274 | CD80 | ENSBTAP00000008067 | ENSBTAP00000070219 | Programmed cell death-ligand 1. | CD80 molecule. | 0.990 |
| CD274 | CD83 | ENSBTAP00000008067 | ENSBTAP00000068556 | Programmed cell death-ligand 1. | Uncharacterized protein. | 0.699 |
| CD274 | CD86 | ENSBTAP00000008067 | ENSBTAP00000071927 | Programmed cell death-ligand 1. | CD86 molecule. | 0.688 |
| CD274 | CSF2 | ENSBTAP00000008067 | ENSBTAP00000002054 | Programmed cell death-ligand 1. | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. | 0.740 |
| CD274 | CTLA4 | ENSBTAP00000008067 | ENSBTAP00000017527 | Programmed cell death-ligand 1. | Cytotoxic T-lymphocyte-associated protein 4. | 0.923 |
| CD274 | IFNG | ENSBTAP00000008067 | ENSBTAP00000016634 | Programmed cell death-ligand 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.898 |
| CD274 | IL10 | ENSBTAP00000008067 | ENSBTAP00000059310 | Programmed cell death-ligand 1. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.802 |
| CD28 | CD274 | ENSBTAP00000069428 | ENSBTAP00000008067 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | Programmed cell death-ligand 1. | 0.511 |
| CD28 | CD4 | ENSBTAP00000069428 | ENSBTAP00000037566 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | CD4 molecule. | 0.769 |
| CD28 | CD40 | ENSBTAP00000069428 | ENSBTAP00000027630 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.420 |
| CD28 | CD80 | ENSBTAP00000069428 | ENSBTAP00000070219 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | CD80 molecule. | 0.987 |
| CD28 | CD86 | ENSBTAP00000069428 | ENSBTAP00000071927 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | CD86 molecule. | 0.988 |
| CD28 | CTLA4 | ENSBTAP00000069428 | ENSBTAP00000017527 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | Cytotoxic T-lymphocyte-associated protein 4. | 0.684 |
| CD28 | IFNG | ENSBTAP00000069428 | ENSBTAP00000016634 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.782 |
| CD28 | IL10 | ENSBTAP00000069428 | ENSBTAP00000059310 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] | 0.564 |
| CD4 | CD274 | ENSBTAP00000037566 | ENSBTAP00000008067 | CD4 molecule. | Programmed cell death-ligand 1. | 0.950 |
| CD4 | CD28 | ENSBTAP00000037566 | ENSBTAP00000069428 | CD4 molecule. | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. | 0.769 |
