node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKR1B10 | AKR1C4 | ENSBTAP00000002073 | ENSBTAP00000014044 | Aldo_ket_red domain-containing protein. | Dihydrodiol dehydrogenase 3. | 0.689 |
AKR1B10 | CBR1 | ENSBTAP00000002073 | ENSBTAP00000072333 | Aldo_ket_red domain-containing protein. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.965 |
AKR1B10 | LOC506594 | ENSBTAP00000002073 | ENSBTAP00000039157 | Aldo_ket_red domain-containing protein. | Aldo_ket_red domain-containing protein. | 0.702 |
AKR1B10 | LOC782922 | ENSBTAP00000002073 | ENSBTAP00000024086 | Aldo_ket_red domain-containing protein. | Prostaglandin F synthase 2; Catalyzes the reduction of PGD(2) and PGH(2) to PGF(2 alpha) and a stereoisomer, respectively. It has a broad substrate specificity and reduces also other carbonyl compounds. | 0.439 |
AKR1B10 | MGC127133 | ENSBTAP00000002073 | ENSBTAP00000040872 | Aldo_ket_red domain-containing protein. | 20-beta-hydroxysteroid dehydrogenase-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.941 |
AKR1C4 | AKR1B10 | ENSBTAP00000014044 | ENSBTAP00000002073 | Dihydrodiol dehydrogenase 3. | Aldo_ket_red domain-containing protein. | 0.689 |
AKR1C4 | CBR1 | ENSBTAP00000014044 | ENSBTAP00000072333 | Dihydrodiol dehydrogenase 3. | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 0.971 |
AKR1C4 | LOC506594 | ENSBTAP00000014044 | ENSBTAP00000039157 | Dihydrodiol dehydrogenase 3. | Aldo_ket_red domain-containing protein. | 0.468 |
AKR1C4 | LOC782922 | ENSBTAP00000014044 | ENSBTAP00000024086 | Dihydrodiol dehydrogenase 3. | Prostaglandin F synthase 2; Catalyzes the reduction of PGD(2) and PGH(2) to PGF(2 alpha) and a stereoisomer, respectively. It has a broad substrate specificity and reduces also other carbonyl compounds. | 0.435 |
AKR1C4 | MGC127133 | ENSBTAP00000014044 | ENSBTAP00000040872 | Dihydrodiol dehydrogenase 3. | 20-beta-hydroxysteroid dehydrogenase-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.969 |
AKR1C4 | PTGS2 | ENSBTAP00000014044 | ENSBTAP00000018774 | Dihydrodiol dehydrogenase 3. | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] | 0.469 |
CBR1 | AKR1B10 | ENSBTAP00000072333 | ENSBTAP00000002073 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Aldo_ket_red domain-containing protein. | 0.965 |
CBR1 | AKR1C4 | ENSBTAP00000072333 | ENSBTAP00000014044 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Dihydrodiol dehydrogenase 3. | 0.971 |
CBR1 | LOC506594 | ENSBTAP00000072333 | ENSBTAP00000039157 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Aldo_ket_red domain-containing protein. | 0.961 |
CBR1 | LOC782922 | ENSBTAP00000072333 | ENSBTAP00000024086 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Prostaglandin F synthase 2; Catalyzes the reduction of PGD(2) and PGH(2) to PGF(2 alpha) and a stereoisomer, respectively. It has a broad substrate specificity and reduces also other carbonyl compounds. | 0.435 |
CBR1 | MGC127133 | ENSBTAP00000072333 | ENSBTAP00000040872 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | 20-beta-hydroxysteroid dehydrogenase-like; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.904 |
CBR1 | PTGS2 | ENSBTAP00000072333 | ENSBTAP00000018774 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] | 0.433 |
LOC112441473 | LOC782922 | ENSBTAP00000070733 | ENSBTAP00000024086 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | Prostaglandin F synthase 2; Catalyzes the reduction of PGD(2) and PGH(2) to PGF(2 alpha) and a stereoisomer, respectively. It has a broad substrate specificity and reduces also other carbonyl compounds. | 0.435 |
LOC506594 | AKR1B10 | ENSBTAP00000039157 | ENSBTAP00000002073 | Aldo_ket_red domain-containing protein. | Aldo_ket_red domain-containing protein. | 0.702 |
LOC506594 | AKR1C4 | ENSBTAP00000039157 | ENSBTAP00000014044 | Aldo_ket_red domain-containing protein. | Dihydrodiol dehydrogenase 3. | 0.468 |