STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRTCAP3Keratinocyte-associated protein 3. (314 aa)    
Predicted Functional Partners:
CCDC121
DUF4515 domain-containing protein.
      
 0.880
TSPEAR
Thrombospondin type laminin G domain and EAR repeats.
      
 0.813
PTPN3
Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.
      
 0.775
ZNF512
Zinc finger protein 512; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.741
GPRC5A
G protein-coupled receptor class C group 5 member A.
      
 0.723
KIF16B
Kinesin family member 16B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.717
FNDC4
Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
      
 0.684
NBEA
Neurobeachin.
      
 0.680
NRBP1
Nuclear receptor binding protein 1.
 
    
 0.675
PIK3R4
Phosphoinositide-3-kinase regulatory subunit 4.
      
 0.644
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.