node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG5 | CASP8 | ENSBTAP00000007100 | ENSBTAP00000062824 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.836 |
ATG5 | FADD | ENSBTAP00000007100 | ENSBTAP00000024322 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). | 0.986 |
ATG5 | MYD88 | ENSBTAP00000007100 | ENSBTAP00000000735 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of [...] | 0.434 |
ATG5 | RIPK1 | ENSBTAP00000007100 | ENSBTAP00000008367 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | Receptor (TNFRSF)-interacting serine-threonine kinase 1. | 0.560 |
ATG5 | RIPK3 | ENSBTAP00000007100 | ENSBTAP00000024511 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | Receptor interacting serine/threonine kinase 3. | 0.415 |
CASP8 | ATG5 | ENSBTAP00000062824 | ENSBTAP00000007100 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] | 0.836 |
CASP8 | CFLAR | ENSBTAP00000062824 | ENSBTAP00000073134 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | 0.992 |
CASP8 | FADD | ENSBTAP00000062824 | ENSBTAP00000024322 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). | 0.999 |
CASP8 | FAS | ENSBTAP00000062824 | ENSBTAP00000014282 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). | 0.986 |
CASP8 | MYD88 | ENSBTAP00000062824 | ENSBTAP00000000735 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of [...] | 0.662 |
CASP8 | RIPK1 | ENSBTAP00000062824 | ENSBTAP00000008367 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Receptor (TNFRSF)-interacting serine-threonine kinase 1. | 0.999 |
CASP8 | RIPK3 | ENSBTAP00000062824 | ENSBTAP00000024511 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.999 |
CASP8 | TNFRSF1A | ENSBTAP00000062824 | ENSBTAP00000071830 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). | 0.912 |
CASP8 | TRADD | ENSBTAP00000062824 | ENSBTAP00000016776 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN [...] | 0.999 |
CASP8 | TRAF2 | ENSBTAP00000062824 | ENSBTAP00000013869 | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.939 |
CFLAR | CASP8 | ENSBTAP00000073134 | ENSBTAP00000062824 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.992 |
CFLAR | FADD | ENSBTAP00000073134 | ENSBTAP00000024322 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity). | 0.993 |
CFLAR | FAS | ENSBTAP00000073134 | ENSBTAP00000014282 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). | 0.899 |
CFLAR | RIPK1 | ENSBTAP00000073134 | ENSBTAP00000008367 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Receptor (TNFRSF)-interacting serine-threonine kinase 1. | 0.889 |
CFLAR | RIPK3 | ENSBTAP00000073134 | ENSBTAP00000024511 | CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 3. | 0.633 |