| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH2 | ALDH3A1 | ENSBTAP00000011521 | ENSBTAP00000028125 | Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | 0.722 |
| ALDH2 | ALDH3A2 | ENSBTAP00000011521 | ENSBTAP00000059321 | Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. | 0.946 |
| ALDH2 | CYP2E1 | ENSBTAP00000011521 | ENSBTAP00000024437 | Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.907 |
| ALDH3A1 | ALDH2 | ENSBTAP00000028125 | ENSBTAP00000011521 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. | 0.722 |
| ALDH3A1 | CYP1A2 | ENSBTAP00000028125 | ENSBTAP00000000094 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.570 |
| ALDH3A1 | CYP2E1 | ENSBTAP00000028125 | ENSBTAP00000024437 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.900 |
| ALDH3A1 | EPHX1 | ENSBTAP00000028125 | ENSBTAP00000070698 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.549 |
| ALDH3A2 | ALDH2 | ENSBTAP00000059321 | ENSBTAP00000011521 | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. | Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. | 0.946 |
| ALDH3A2 | CYP2E1 | ENSBTAP00000059321 | ENSBTAP00000024437 | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.880 |
| ALDH3A2 | EPHX1 | ENSBTAP00000059321 | ENSBTAP00000070698 | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.633 |
| CYP1A2 | ALDH3A1 | ENSBTAP00000000094 | ENSBTAP00000028125 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | 0.570 |
| CYP1A2 | CYP2E1 | ENSBTAP00000000094 | ENSBTAP00000024437 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.910 |
| CYP1A2 | CYP7A1 | ENSBTAP00000000094 | ENSBTAP00000006957 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.956 |
| CYP1A2 | EPHX1 | ENSBTAP00000000094 | ENSBTAP00000070698 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. | 0.965 |
| CYP1A2 | LOC781988 | ENSBTAP00000000094 | ENSBTAP00000029965 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.796 |
| CYP1A2 | UGT2A1 | ENSBTAP00000000094 | ENSBTAP00000051040 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.975 |
| CYP2E1 | ALDH2 | ENSBTAP00000024437 | ENSBTAP00000011521 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Aldehyde dehydrogenase, mitochondrial; Belongs to the aldehyde dehydrogenase family. | 0.907 |
| CYP2E1 | ALDH3A1 | ENSBTAP00000024437 | ENSBTAP00000028125 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). | 0.900 |
| CYP2E1 | ALDH3A2 | ENSBTAP00000024437 | ENSBTAP00000059321 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Aldehyde dehydrogenase 3 family member A2; Belongs to the aldehyde dehydrogenase family. | 0.880 |
| CYP2E1 | CYP1A2 | ENSBTAP00000024437 | ENSBTAP00000000094 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.910 |
