CYP2E1 protein (Bos taurus) - STRING interaction network

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CYP2E1

Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. (509 aa)

Predicted Functional Partners:

UGT1A1

0.973

UGT2B10

0.968

UGT2A1

0.967

LOC615303

0.965

LOC100138004

0.965

MGC152010

0.965

LOC100138908

0.965

LOC781988

0.964

LOC530553

0.964

ALDH3A1

0.963

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH3A1	CYP2E1	ENSBTAP00000028125	ENSBTAP00000024437	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	0.963
ALDH3A1	UGT1A1	ENSBTAP00000028125	ENSBTAP00000036928	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.490
CYP2E1	ALDH3A1	ENSBTAP00000024437	ENSBTAP00000028125	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	0.963
CYP2E1	LOC100138004	ENSBTAP00000024437	ENSBTAP00000029956	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.965
CYP2E1	LOC100138908	ENSBTAP00000024437	ENSBTAP00000062781	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.965
CYP2E1	LOC530553	ENSBTAP00000024437	ENSBTAP00000069492	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.964
CYP2E1	LOC615303	ENSBTAP00000024437	ENSBTAP00000004581	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.965
CYP2E1	LOC781988	ENSBTAP00000024437	ENSBTAP00000029965	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.964
CYP2E1	MGC152010	ENSBTAP00000024437	ENSBTAP00000050702	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.965
CYP2E1	UGT1A1	ENSBTAP00000024437	ENSBTAP00000036928	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.973
CYP2E1	UGT2A1	ENSBTAP00000024437	ENSBTAP00000051040	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.967
CYP2E1	UGT2B10	ENSBTAP00000024437	ENSBTAP00000022664	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.968
LOC100138004	CYP2E1	ENSBTAP00000029956	ENSBTAP00000024437	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.	0.965
LOC100138004	LOC100138908	ENSBTAP00000029956	ENSBTAP00000062781	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.478
LOC100138004	LOC530553	ENSBTAP00000029956	ENSBTAP00000069492	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.412
LOC100138004	LOC615303	ENSBTAP00000029956	ENSBTAP00000004581	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.449
LOC100138004	LOC781988	ENSBTAP00000029956	ENSBTAP00000029965	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.435
LOC100138004	MGC152010	ENSBTAP00000029956	ENSBTAP00000050702	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.455
LOC100138004	UGT1A1	ENSBTAP00000029956	ENSBTAP00000036928	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.427
LOC100138004	UGT2B10	ENSBTAP00000029956	ENSBTAP00000022664	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.	0.408

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