node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGMAT | AMD1 | ENSBTAP00000067134 | ENSBTAP00000065674 | Agmatinase; Belongs to the arginase family. | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | 0.692 |
AGMAT | ARG1 | ENSBTAP00000067134 | ENSBTAP00000016461 | Agmatinase; Belongs to the arginase family. | Arginase-1. | 0.490 |
AGMAT | ARG2 | ENSBTAP00000067134 | ENSBTAP00000053934 | Agmatinase; Belongs to the arginase family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.526 |
AGMAT | AZIN1 | ENSBTAP00000067134 | ENSBTAP00000010441 | Agmatinase; Belongs to the arginase family. | Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.645 |
AGMAT | ODC1 | ENSBTAP00000067134 | ENSBTAP00000005575 | Agmatinase; Belongs to the arginase family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.851 |
AGMAT | SMOX | ENSBTAP00000067134 | ENSBTAP00000001472 | Agmatinase; Belongs to the arginase family. | Spermine oxidase. | 0.665 |
AGMAT | SMS | ENSBTAP00000067134 | ENSBTAP00000071420 | Agmatinase; Belongs to the arginase family. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.908 |
AGMAT | SRM | ENSBTAP00000067134 | ENSBTAP00000006978 | Agmatinase; Belongs to the arginase family. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.904 |
AMD1 | AGMAT | ENSBTAP00000065674 | ENSBTAP00000067134 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Agmatinase; Belongs to the arginase family. | 0.692 |
AMD1 | ARG1 | ENSBTAP00000065674 | ENSBTAP00000016461 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Arginase-1. | 0.607 |
AMD1 | ARG2 | ENSBTAP00000065674 | ENSBTAP00000053934 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signal [...] | 0.773 |
AMD1 | AZIN1 | ENSBTAP00000065674 | ENSBTAP00000010441 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.784 |
AMD1 | MAT2A | ENSBTAP00000065674 | ENSBTAP00000061409 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. | 0.969 |
AMD1 | MTAP | ENSBTAP00000065674 | ENSBTAP00000045533 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.651 |
AMD1 | ODC1 | ENSBTAP00000065674 | ENSBTAP00000005575 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.950 |
AMD1 | SMOX | ENSBTAP00000065674 | ENSBTAP00000001472 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermine oxidase. | 0.847 |
AMD1 | SMS | ENSBTAP00000065674 | ENSBTAP00000071420 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.996 |
AMD1 | SRM | ENSBTAP00000065674 | ENSBTAP00000006978 | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | Spermidine synthase; Belongs to the spermidine/spermine synthase family. | 0.996 |
ARG1 | AGMAT | ENSBTAP00000016461 | ENSBTAP00000067134 | Arginase-1. | Agmatinase; Belongs to the arginase family. | 0.490 |
ARG1 | AMD1 | ENSBTAP00000016461 | ENSBTAP00000065674 | Arginase-1. | S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family. | 0.607 |