| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATL1 | REEP1 | ENSBTAP00000019032 | ENSBTAP00000064769 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Receptor expression-enhancing protein. | 0.895 |
| ATL1 | SPAST | ENSBTAP00000019032 | ENSBTAP00000044166 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.904 |
| ATL1 | VAPB | ENSBTAP00000019032 | ENSBTAP00000023164 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.421 |
| ATL1 | ZFYVE27 | ENSBTAP00000019032 | ENSBTAP00000071500 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.761 |
| ENSBTAP00000067530 | STARD3 | ENSBTAP00000067530 | ENSBTAP00000015578 | MSP domain-containing protein. | StAR related lipid transfer domain containing 3. | 0.956 |
| ENSBTAP00000067530 | STARD3NL | ENSBTAP00000067530 | ENSBTAP00000050169 | MSP domain-containing protein. | STARD3 N-terminal like. | 0.553 |
| ENSBTAP00000067530 | VAPB | ENSBTAP00000067530 | ENSBTAP00000023164 | MSP domain-containing protein. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.961 |
| ENSBTAP00000067530 | ZFYVE27 | ENSBTAP00000067530 | ENSBTAP00000071500 | MSP domain-containing protein. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.651 |
| FYCO1 | STARD3 | ENSBTAP00000020845 | ENSBTAP00000015578 | FYVE and coiled-coil domain containing 1. | StAR related lipid transfer domain containing 3. | 0.600 |
| FYCO1 | STARD3NL | ENSBTAP00000020845 | ENSBTAP00000050169 | FYVE and coiled-coil domain containing 1. | STARD3 N-terminal like. | 0.590 |
| FYCO1 | ZFYVE27 | ENSBTAP00000020845 | ENSBTAP00000071500 | FYVE and coiled-coil domain containing 1. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.767 |
| PDZD8 | STARD3 | ENSBTAP00000015152 | ENSBTAP00000015578 | PDZ domain containing 8. | StAR related lipid transfer domain containing 3. | 0.688 |
| PDZD8 | STARD3NL | ENSBTAP00000015152 | ENSBTAP00000050169 | PDZ domain containing 8. | STARD3 N-terminal like. | 0.426 |
| PDZD8 | VAPA | ENSBTAP00000015152 | ENSBTAP00000064278 | PDZ domain containing 8. | Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. | 0.553 |
| PDZD8 | VAPB | ENSBTAP00000015152 | ENSBTAP00000023164 | PDZ domain containing 8. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.716 |
| PDZD8 | ZFYVE27 | ENSBTAP00000015152 | ENSBTAP00000071500 | PDZ domain containing 8. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.761 |
| REEP1 | ATL1 | ENSBTAP00000064769 | ENSBTAP00000019032 | Receptor expression-enhancing protein. | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development. | 0.895 |
| REEP1 | SPAST | ENSBTAP00000064769 | ENSBTAP00000044166 | Receptor expression-enhancing protein. | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] | 0.812 |
| REEP1 | VAPB | ENSBTAP00000064769 | ENSBTAP00000023164 | Receptor expression-enhancing protein. | Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. | 0.563 |
| REEP1 | ZFYVE27 | ENSBTAP00000064769 | ENSBTAP00000071500 | Receptor expression-enhancing protein. | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of neuronal cell polarity. Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner. Contributes to both the formation and stabilization of the tubular ER network. Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections. Acts as an adapter protein that facilitates the interaction of KIF5A with VAPA, VAPB, [...] | 0.790 |
