node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABL1 | ABL2 | ENSBTAP00000058693 | ENSBTAP00000020006 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.940 |
ABL1 | DOK1 | ENSBTAP00000058693 | ENSBTAP00000024727 | Tyrosine-protein kinase. | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | 0.551 |
ABL2 | ABL1 | ENSBTAP00000020006 | ENSBTAP00000058693 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.940 |
ABL2 | DOK1 | ENSBTAP00000020006 | ENSBTAP00000024727 | Tyrosine-protein kinase. | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | 0.551 |
DOK1 | ABL1 | ENSBTAP00000024727 | ENSBTAP00000058693 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Tyrosine-protein kinase. | 0.551 |
DOK1 | ABL2 | ENSBTAP00000024727 | ENSBTAP00000020006 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Tyrosine-protein kinase. | 0.551 |
DOK1 | DQX1 | ENSBTAP00000024727 | ENSBTAP00000033112 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | ATP-dependent RNA helicase DQX1. | 0.684 |
DOK1 | FADS3 | ENSBTAP00000024727 | ENSBTAP00000020612 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Fatty acid desaturase 3; Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6). | 0.543 |
DOK1 | INPP5D | ENSBTAP00000024727 | ENSBTAP00000059740 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Inositol polyphosphate-5-phosphatase D. | 0.689 |
DOK1 | PTK6 | ENSBTAP00000024727 | ENSBTAP00000053595 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Tyrosine-protein kinase. | 0.909 |
DOK1 | RASA1 | ENSBTAP00000024727 | ENSBTAP00000012583 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. | 0.884 |
DOK1 | RET | ENSBTAP00000024727 | ENSBTAP00000000744 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. | 0.914 |
DOK1 | TEC | ENSBTAP00000024727 | ENSBTAP00000043974 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Tyrosine-protein kinase. | 0.708 |
DOK1 | TRAM1L1 | ENSBTAP00000024727 | ENSBTAP00000055843 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | Translocating chain-associated membrane protein; Belongs to the TRAM family. | 0.567 |
DQX1 | DOK1 | ENSBTAP00000033112 | ENSBTAP00000024727 | ATP-dependent RNA helicase DQX1. | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | 0.684 |
FADS3 | DOK1 | ENSBTAP00000020612 | ENSBTAP00000024727 | Fatty acid desaturase 3; Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6). | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | 0.543 |
FADS3 | TRAM1L1 | ENSBTAP00000020612 | ENSBTAP00000055843 | Fatty acid desaturase 3; Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6). | Translocating chain-associated membrane protein; Belongs to the TRAM family. | 0.590 |
INPP5D | DOK1 | ENSBTAP00000059740 | ENSBTAP00000024727 | Inositol polyphosphate-5-phosphatase D. | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | 0.689 |
PTK6 | DOK1 | ENSBTAP00000053595 | ENSBTAP00000024727 | Tyrosine-protein kinase. | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity). | 0.909 |
PTK6 | RASA1 | ENSBTAP00000053595 | ENSBTAP00000012583 | Tyrosine-protein kinase. | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21. | 0.539 |