node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FIP1L1 | INTS1 | ENSBTAP00000027525 | ENSBTAP00000000845 | Factor interacting with PAPOLA and CPSF1. | Integrator complex subunit 1. | 0.709 |
FIP1L1 | INTS11 | ENSBTAP00000027525 | ENSBTAP00000058314 | Factor interacting with PAPOLA and CPSF1. | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] | 0.754 |
FIP1L1 | INTS3 | ENSBTAP00000027525 | ENSBTAP00000008186 | Factor interacting with PAPOLA and CPSF1. | Integrator complex subunit 3. | 0.676 |
FIP1L1 | INTS6 | ENSBTAP00000027525 | ENSBTAP00000003868 | Factor interacting with PAPOLA and CPSF1. | Integrator complex subunit 6. | 0.693 |
FIP1L1 | INTS9 | ENSBTAP00000027525 | ENSBTAP00000046018 | Factor interacting with PAPOLA and CPSF1. | Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. | 0.661 |
FIP1L1 | NABP1 | ENSBTAP00000027525 | ENSBTAP00000064211 | Factor interacting with PAPOLA and CPSF1. | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.640 |
INIP | INTS3 | ENSBTAP00000025666 | ENSBTAP00000008186 | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). | Integrator complex subunit 3. | 0.992 |
INIP | INTS6 | ENSBTAP00000025666 | ENSBTAP00000003868 | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). | Integrator complex subunit 6. | 0.524 |
INIP | NABP1 | ENSBTAP00000025666 | ENSBTAP00000064211 | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.885 |
INTS1 | FIP1L1 | ENSBTAP00000000845 | ENSBTAP00000027525 | Integrator complex subunit 1. | Factor interacting with PAPOLA and CPSF1. | 0.709 |
INTS1 | INTS11 | ENSBTAP00000000845 | ENSBTAP00000058314 | Integrator complex subunit 1. | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] | 0.999 |
INTS1 | INTS3 | ENSBTAP00000000845 | ENSBTAP00000008186 | Integrator complex subunit 1. | Integrator complex subunit 3. | 0.998 |
INTS1 | INTS5 | ENSBTAP00000000845 | ENSBTAP00000013803 | Integrator complex subunit 1. | Integrator complex subunit 5. | 0.998 |
INTS1 | INTS6 | ENSBTAP00000000845 | ENSBTAP00000003868 | Integrator complex subunit 1. | Integrator complex subunit 6. | 0.999 |
INTS1 | INTS9 | ENSBTAP00000000845 | ENSBTAP00000046018 | Integrator complex subunit 1. | Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INTS9 subfamily. | 0.999 |
INTS1 | NABP1 | ENSBTAP00000000845 | ENSBTAP00000064211 | Integrator complex subunit 1. | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.833 |
INTS11 | FIP1L1 | ENSBTAP00000058314 | ENSBTAP00000027525 | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] | Factor interacting with PAPOLA and CPSF1. | 0.754 |
INTS11 | INTS1 | ENSBTAP00000058314 | ENSBTAP00000000845 | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] | Integrator complex subunit 1. | 0.999 |
INTS11 | INTS3 | ENSBTAP00000058314 | ENSBTAP00000008186 | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] | Integrator complex subunit 3. | 0.997 |
INTS11 | INTS5 | ENSBTAP00000058314 | ENSBTAP00000013803 | Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] | Integrator complex subunit 5. | 0.998 |