STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBXL3F-box and leucine rich repeat protein 3. (321 aa)    
Predicted Functional Partners:
CRY1
Cryptochrome circadian regulator 1.
    
 0.997
CRY2
Cryptochrome circadian regulator 2.
    
 
 0.972
SKP1
S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]
   
 
 0.869
CUL1
Cullin 1; Belongs to the cullin family.
   
 
 0.778
MYCBP2
MYC binding protein 2.
 
    
 0.706
ENSBTAP00000057099
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
   
 
 0.686
ENSBTAP00000069011
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
   
 
 0.686
ENSBTAP00000072193
Skp1_POZ domain-containing protein; Belongs to the SKP1 family.
   
 
 0.686
ENSBTAP00000072606
Uncharacterized protein; Belongs to the SKP1 family.
   
 
 0.686
CLOCK
Clock circadian regulator.
      
 0.680
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.