| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AICDA | APOBEC4 | ENSBTAP00000025096 | ENSBTAP00000053895 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4. | 0.834 |
| AICDA | BACH2 | ENSBTAP00000025096 | ENSBTAP00000070325 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | BTB domain and CNC homolog 2. | 0.822 |
| AICDA | BCL6 | ENSBTAP00000025096 | ENSBTAP00000061297 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | BCL6 transcription repressor. | 0.910 |
| AICDA | BCR | ENSBTAP00000025096 | ENSBTAP00000065181 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | BCR activator of RhoGEF and GTPase. | 0.804 |
| AICDA | CD19 | ENSBTAP00000025096 | ENSBTAP00000008598 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | CD19 molecule. | 0.828 |
| AICDA | CD40 | ENSBTAP00000025096 | ENSBTAP00000027630 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.824 |
| AICDA | CDA | ENSBTAP00000025096 | ENSBTAP00000073428 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | CMP/dCMP-type deaminase domain-containing protein. | 0.803 |
| AICDA | IL4 | ENSBTAP00000025096 | ENSBTAP00000021215 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.830 |
| AICDA | IRF4 | ENSBTAP00000025096 | ENSBTAP00000003812 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | Interferon regulatory factor 4. | 0.846 |
| AICDA | PAX5 | ENSBTAP00000025096 | ENSBTAP00000072830 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | Paired box 5. | 0.842 |
| APOBEC4 | AICDA | ENSBTAP00000053895 | ENSBTAP00000025096 | Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4. | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | 0.834 |
| APOBEC4 | CDA | ENSBTAP00000053895 | ENSBTAP00000073428 | Apolipoprotein B mRNA editing enzyme catalytic polypeptide like 4. | CMP/dCMP-type deaminase domain-containing protein. | 0.655 |
| BACH2 | AICDA | ENSBTAP00000070325 | ENSBTAP00000025096 | BTB domain and CNC homolog 2. | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. | 0.822 |
| BACH2 | BCL6 | ENSBTAP00000070325 | ENSBTAP00000061297 | BTB domain and CNC homolog 2. | BCL6 transcription repressor. | 0.602 |
| BACH2 | BCR | ENSBTAP00000070325 | ENSBTAP00000065181 | BTB domain and CNC homolog 2. | BCR activator of RhoGEF and GTPase. | 0.541 |
| BACH2 | CD19 | ENSBTAP00000070325 | ENSBTAP00000008598 | BTB domain and CNC homolog 2. | CD19 molecule. | 0.506 |
| BACH2 | CD40 | ENSBTAP00000070325 | ENSBTAP00000027630 | BTB domain and CNC homolog 2. | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). | 0.453 |
| BACH2 | IL4 | ENSBTAP00000070325 | ENSBTAP00000021215 | BTB domain and CNC homolog 2. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.492 |
| BACH2 | IRF4 | ENSBTAP00000070325 | ENSBTAP00000003812 | BTB domain and CNC homolog 2. | Interferon regulatory factor 4. | 0.877 |
| BACH2 | PAX5 | ENSBTAP00000070325 | ENSBTAP00000072830 | BTB domain and CNC homolog 2. | Paired box 5. | 0.848 |
