node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FLNA | FLNC | ENSBTAP00000030179 | ENSBTAP00000061306 | Filamin A. | Filamin C. | 0.910 |
FLNA | ILK | ENSBTAP00000030179 | ENSBTAP00000000927 | Filamin A. | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | 0.769 |
FLNA | ITGA4 | ENSBTAP00000030179 | ENSBTAP00000012194 | Filamin A. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.743 |
FLNA | ITGB7 | ENSBTAP00000030179 | ENSBTAP00000025279 | Filamin A. | Integrin beta; Belongs to the integrin beta chain family. | 0.952 |
FLNA | SRC | ENSBTAP00000030179 | ENSBTAP00000011767 | Filamin A. | Tyrosine-protein kinase. | 0.670 |
FLNA | TLN1 | ENSBTAP00000030179 | ENSBTAP00000071988 | Filamin A. | Talin 1. | 0.987 |
FLNA | TLN2 | ENSBTAP00000030179 | ENSBTAP00000064968 | Filamin A. | Talin 2. | 0.959 |
FLNC | FLNA | ENSBTAP00000061306 | ENSBTAP00000030179 | Filamin C. | Filamin A. | 0.910 |
FLNC | ILK | ENSBTAP00000061306 | ENSBTAP00000000927 | Filamin C. | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. | 0.539 |
FLNC | ITGA4 | ENSBTAP00000061306 | ENSBTAP00000012194 | Filamin C. | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.736 |
FLNC | ITGB7 | ENSBTAP00000061306 | ENSBTAP00000025279 | Filamin C. | Integrin beta; Belongs to the integrin beta chain family. | 0.946 |
FLNC | SRC | ENSBTAP00000061306 | ENSBTAP00000011767 | Filamin C. | Tyrosine-protein kinase. | 0.449 |
FLNC | TLN1 | ENSBTAP00000061306 | ENSBTAP00000071988 | Filamin C. | Talin 1. | 0.962 |
FLNC | TLN2 | ENSBTAP00000061306 | ENSBTAP00000064968 | Filamin C. | Talin 2. | 0.948 |
FN1 | ITGA4 | ENSBTAP00000010925 | ENSBTAP00000012194 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. | 0.918 |
FN1 | ITGAE | ENSBTAP00000010925 | ENSBTAP00000020307 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin subunit alpha E; Belongs to the integrin alpha chain family. | 0.670 |
FN1 | ITGB7 | ENSBTAP00000010925 | ENSBTAP00000025279 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Integrin beta; Belongs to the integrin beta chain family. | 0.953 |
FN1 | PTK2 | ENSBTAP00000010925 | ENSBTAP00000065036 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.683 |
FN1 | SRC | ENSBTAP00000010925 | ENSBTAP00000011767 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Tyrosine-protein kinase. | 0.600 |
FN1 | TLN1 | ENSBTAP00000010925 | ENSBTAP00000071988 | Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). | Talin 1. | 0.619 |