node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APPL1 | EEA1 | ENSBTAP00000008971 | ENSBTAP00000063541 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Early endosome antigen 1. | 0.797 |
APPL1 | LOC781001 | ENSBTAP00000008971 | ENSBTAP00000025807 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | RAB21, member RAS oncogene family. | 0.645 |
APPL1 | RABGEF1 | ENSBTAP00000008971 | ENSBTAP00000005011 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. | 0.586 |
APPL1 | RBSN | ENSBTAP00000008971 | ENSBTAP00000064956 | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | Rabenosyn, RAB effector. | 0.768 |
DENND1B | DENND1C | ENSBTAP00000049155 | ENSBTAP00000042504 | DENN domain containing 1B. | DENN domain containing 1C. | 0.489 |
DENND1B | LOC781001 | ENSBTAP00000049155 | ENSBTAP00000025807 | DENN domain containing 1B. | RAB21, member RAS oncogene family. | 0.730 |
DENND1B | RABGEF1 | ENSBTAP00000049155 | ENSBTAP00000005011 | DENN domain containing 1B. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. | 0.698 |
DENND1C | DENND1B | ENSBTAP00000042504 | ENSBTAP00000049155 | DENN domain containing 1C. | DENN domain containing 1B. | 0.489 |
DENND1C | LOC781001 | ENSBTAP00000042504 | ENSBTAP00000025807 | DENN domain containing 1C. | RAB21, member RAS oncogene family. | 0.651 |
DENND1C | RABGEF1 | ENSBTAP00000042504 | ENSBTAP00000005011 | DENN domain containing 1C. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. | 0.424 |
EEA1 | APPL1 | ENSBTAP00000063541 | ENSBTAP00000008971 | Early endosome antigen 1. | Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. | 0.797 |
EEA1 | GAPVD1 | ENSBTAP00000063541 | ENSBTAP00000068422 | Early endosome antigen 1. | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | 0.489 |
EEA1 | LOC781001 | ENSBTAP00000063541 | ENSBTAP00000025807 | Early endosome antigen 1. | RAB21, member RAS oncogene family. | 0.632 |
EEA1 | RABGEF1 | ENSBTAP00000063541 | ENSBTAP00000005011 | Early endosome antigen 1. | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. | 0.884 |
EEA1 | RABIF | ENSBTAP00000063541 | ENSBTAP00000018029 | Early endosome antigen 1. | RAB interacting factor. | 0.566 |
EEA1 | VAMP7 | ENSBTAP00000063541 | ENSBTAP00000066954 | Early endosome antigen 1. | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.503 |
GAPVD1 | EEA1 | ENSBTAP00000068422 | ENSBTAP00000063541 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Early endosome antigen 1. | 0.489 |
GAPVD1 | LOC781001 | ENSBTAP00000068422 | ENSBTAP00000025807 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | RAB21, member RAS oncogene family. | 0.672 |
GAPVD1 | RABGEF1 | ENSBTAP00000068422 | ENSBTAP00000005011 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase. | 0.618 |
GAPVD1 | VAMP7 | ENSBTAP00000068422 | ENSBTAP00000066954 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.579 |