node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F2 | FURIN | ENSBTAP00000009406 | ENSBTAP00000065278 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | 0.808 |
F2 | GGCX | ENSBTAP00000009406 | ENSBTAP00000027811 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | 0.925 |
F2 | PROZ | ENSBTAP00000009406 | ENSBTAP00000066682 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 0.566 |
F2 | SERPINA10 | ENSBTAP00000009406 | ENSBTAP00000013050 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Serpin family A member 10; Belongs to the serpin family. | 0.595 |
F2 | SERPINC1 | ENSBTAP00000009406 | ENSBTAP00000072452 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.999 |
FURIN | F2 | ENSBTAP00000065278 | ENSBTAP00000009406 | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.808 |
FURIN | PROZ | ENSBTAP00000065278 | ENSBTAP00000066682 | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 0.765 |
GGCX | F2 | ENSBTAP00000027811 | ENSBTAP00000009406 | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.925 |
GGCX | PROZ | ENSBTAP00000027811 | ENSBTAP00000066682 | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 0.846 |
HMGCLL1 | PROZ | ENSBTAP00000019954 | ENSBTAP00000066682 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 0.538 |
OR5M11 | PROZ | ENSBTAP00000052041 | ENSBTAP00000066682 | Olfactory receptor. | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 0.621 |
OR5M11 | RDH13 | ENSBTAP00000052041 | ENSBTAP00000029403 | Olfactory receptor. | Retinol dehydrogenase 13 (All-trans/9-cis); Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.621 |
OR5M11 | TMCC2 | ENSBTAP00000052041 | ENSBTAP00000003052 | Olfactory receptor. | Transmembrane and coiled-coil domain family 2. | 0.674 |
PDXP | PROZ | ENSBTAP00000016505 | ENSBTAP00000066682 | Pyridoxal phosphate phosphatase; Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'- phosphate (PMP), with order of substra [...] | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 0.553 |
PROZ | F2 | ENSBTAP00000066682 | ENSBTAP00000009406 | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity); Belongs to the peptidase S1 family. | 0.566 |
PROZ | FURIN | ENSBTAP00000066682 | ENSBTAP00000065278 | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity); Belongs to the peptidase S8 family. Furin subfamily. | 0.765 |
PROZ | GGCX | ENSBTAP00000066682 | ENSBTAP00000027811 | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | 0.846 |
PROZ | HMGCLL1 | ENSBTAP00000066682 | ENSBTAP00000019954 | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | 0.538 |
PROZ | OR5M11 | ENSBTAP00000066682 | ENSBTAP00000052041 | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | Olfactory receptor. | 0.621 |
PROZ | PDXP | ENSBTAP00000066682 | ENSBTAP00000016505 | Vitamin K-dependent protein Z; Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity). Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles; Belongs to the peptidase S1 family. | Pyridoxal phosphate phosphatase; Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'- phosphate (PMP), with order of substra [...] | 0.553 |