STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ANGAngiogenin-1; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs) (By similarity). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. Has very low ribonucle [...] (165 aa)    
Predicted Functional Partners:
ANG2
Angiogenin-2; Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity. Has potent angiogenic activity. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.
  
0.966
SPADH1
Spermadhesin-1; Stimulates cell division and progesterone secretion of bovine granulosa cells in vitro in a potent and dose dependent manner. This protein appears to be a potent growth factor with effects on ovarian granulosa cells.
      
 0.809
LOC101903018
Acrosin inhibitor 1; Strong inhibitor of acrosin.
    
 
 0.694
RNH1
Ribonuclease/angiogenin inhibitor 1.
    
 0.627
SPADH2
Spermadhesin Z13; May be involved in the fertilization process; Belongs to the spermadhesin family.
      
 0.575
A1BG
Alpha-1B-glycoprotein.
      
 0.564
HSTN
Histatherin; Belongs to the histatin/statherin family.
      
 0.531
RNASE6
Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram- negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity).
   
  
 0.489
BSP1
Seminal plasma protein PDC-109; Could enhance the fertilizing capacity of bull spermatozoa upon interaction with heparin-like glycosaminoglycans present in the female genital tract. Exhibits both simulatory and inhibitory actions on the release of pituitary gonadotropins.
      
 0.483
SPESP1
Sperm equatorial segment protein 1; Involved in fertilization ability of sperm.
      
 0.457
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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