node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPIFA1 | BPIFA2B | ENSBTAP00000069828 | ENSBTAP00000026321 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | 0.688 |
BPIFA1 | BPIFB2 | ENSBTAP00000069828 | ENSBTAP00000025557 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI fold containing family B member 2. | 0.799 |
BPIFA1 | BPIFB3 | ENSBTAP00000069828 | ENSBTAP00000022985 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI fold containing family B member 3. | 0.577 |
BPIFA1 | BPIFB5 | ENSBTAP00000069828 | ENSBTAP00000041929 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI1 domain-containing protein. | 0.747 |
BPIFA1 | BPIFB6 | ENSBTAP00000069828 | ENSBTAP00000013339 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI fold containing family B member 6. | 0.793 |
BPIFA1 | LBP | ENSBTAP00000069828 | ENSBTAP00000022428 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. | 0.655 |
BPIFA1 | LOC514978 | ENSBTAP00000069828 | ENSBTAP00000056082 | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | BPI1 domain-containing protein. | 0.656 |
BPIFA2B | BPIFA1 | ENSBTAP00000026321 | ENSBTAP00000069828 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] | 0.688 |
BPIFA2B | BPIFA3 | ENSBTAP00000026321 | ENSBTAP00000050973 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Short palate, lung and nasal epithelium carcinoma associated 3 protein. | 0.741 |
BPIFA2B | BPIFB2 | ENSBTAP00000026321 | ENSBTAP00000025557 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | BPI fold containing family B member 2. | 0.594 |
BPIFA2B | BPIFB3 | ENSBTAP00000026321 | ENSBTAP00000022985 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | BPI fold containing family B member 3. | 0.662 |
BPIFA2B | BPIFB5 | ENSBTAP00000026321 | ENSBTAP00000041929 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | BPI1 domain-containing protein. | 0.743 |
BPIFA2B | BPIFB6 | ENSBTAP00000026321 | ENSBTAP00000013339 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | BPI fold containing family B member 6. | 0.682 |
BPIFA2B | LBP | ENSBTAP00000026321 | ENSBTAP00000022428 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide. | 0.566 |
BPIFA2B | LOC514978 | ENSBTAP00000026321 | ENSBTAP00000056082 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | BPI1 domain-containing protein. | 0.567 |
BPIFA2B | PGLYRP2 | ENSBTAP00000026321 | ENSBTAP00000044262 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Peptidoglycan recognition protein 2. | 0.654 |
BPIFA2B | PGLYRP3 | ENSBTAP00000026321 | ENSBTAP00000063937 | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | Peptidoglycan recognition protein 3. | 0.540 |
BPIFA3 | BPIFA2B | ENSBTAP00000050973 | ENSBTAP00000026321 | Short palate, lung and nasal epithelium carcinoma associated 3 protein. | Short palate, lung and nasal epithelium carcinoma-associated protein 2B; Belongs to the BPI/LBP/Plunc superfamily. Plunc family. | 0.741 |
BPIFA3 | BPIFB2 | ENSBTAP00000050973 | ENSBTAP00000025557 | Short palate, lung and nasal epithelium carcinoma associated 3 protein. | BPI fold containing family B member 2. | 0.687 |
BPIFA3 | BPIFB3 | ENSBTAP00000050973 | ENSBTAP00000022985 | Short palate, lung and nasal epithelium carcinoma associated 3 protein. | BPI fold containing family B member 3. | 0.741 |