| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG2B | GSKIP | ENSBTAP00000030494 | ENSBTAP00000026427 | Autophagy related 2B. | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | 0.683 |
| FAM228B | GSKIP | ENSBTAP00000041212 | ENSBTAP00000026427 | Protein FAM228B; Belongs to the FAM228 family. | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | 0.743 |
| FAM228B | GTF3A | ENSBTAP00000041212 | ENSBTAP00000016732 | Protein FAM228B; Belongs to the FAM228 family. | General transcription factor IIIA. | 0.697 |
| FAM228B | MAN2C1 | ENSBTAP00000041212 | ENSBTAP00000009690 | Protein FAM228B; Belongs to the FAM228 family. | Mannosidase alpha class 2C member 1. | 0.733 |
| FAM228B | PPP1R42 | ENSBTAP00000041212 | ENSBTAP00000014881 | Protein FAM228B; Belongs to the FAM228 family. | Protein phosphatase 1 regulatory subunit 42. | 0.648 |
| FAM228B | TTC22 | ENSBTAP00000041212 | ENSBTAP00000022771 | Protein FAM228B; Belongs to the FAM228 family. | Tetratricopeptide repeat domain 22. | 0.677 |
| FAM228B | UNC13B | ENSBTAP00000041212 | ENSBTAP00000066401 | Protein FAM228B; Belongs to the FAM228 family. | Unc-13 homolog B. | 0.568 |
| FAM228B | USP12 | ENSBTAP00000041212 | ENSBTAP00000058257 | Protein FAM228B; Belongs to the FAM228 family. | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily. | 0.657 |
| GSK3A | GSK3B | ENSBTAP00000059593 | ENSBTAP00000051604 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.903 |
| GSK3A | GSKIP | ENSBTAP00000059593 | ENSBTAP00000026427 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | 0.632 |
| GSK3B | GSK3A | ENSBTAP00000051604 | ENSBTAP00000059593 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.903 |
| GSK3B | GSKIP | ENSBTAP00000051604 | ENSBTAP00000026427 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | 0.904 |
| GSKIP | ATG2B | ENSBTAP00000026427 | ENSBTAP00000030494 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Autophagy related 2B. | 0.683 |
| GSKIP | FAM228B | ENSBTAP00000026427 | ENSBTAP00000041212 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Protein FAM228B; Belongs to the FAM228 family. | 0.743 |
| GSKIP | GSK3A | ENSBTAP00000026427 | ENSBTAP00000059593 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.632 |
| GSKIP | GSK3B | ENSBTAP00000026427 | ENSBTAP00000051604 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.904 |
| GSKIP | GTF3A | ENSBTAP00000026427 | ENSBTAP00000016732 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | General transcription factor IIIA. | 0.626 |
| GSKIP | MAN2C1 | ENSBTAP00000026427 | ENSBTAP00000009690 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Mannosidase alpha class 2C member 1. | 0.662 |
| GSKIP | PPP1R42 | ENSBTAP00000026427 | ENSBTAP00000014881 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Protein phosphatase 1 regulatory subunit 42. | 0.674 |
| GSKIP | TTC22 | ENSBTAP00000026427 | ENSBTAP00000022771 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] | Tetratricopeptide repeat domain 22. | 0.737 |