STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GSKIPGSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] (139 aa)    
Predicted Functional Partners:
GSK3B
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 
 0.904
FAM228B
Protein FAM228B; Belongs to the FAM228 family.
   
  
 0.743
TTC22
Tetratricopeptide repeat domain 22.
      
 0.737
ATG2B
Autophagy related 2B.
      
 0.683
PPP1R42
Protein phosphatase 1 regulatory subunit 42.
      
 0.674
MAN2C1
Mannosidase alpha class 2C member 1.
      
 0.662
UNC13B
Unc-13 homolog B.
      
 0.637
GSK3A
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 
 0.632
GTF3A
General transcription factor IIIA.
      
 0.626
USP12
Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2; Belongs to the peptidase C19 family. USP12/USP46 subfamily.
   
  
 0.594
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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