HAS2 protein (Bos taurus) - STRING interaction network

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HAS2

Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...] (552 aa)

Predicted Functional Partners:

HYAL1

0.873

HYAL2

0.869

CD44

0.842

TNFAIP6

0.841

HYAL4

0.755

SPAM1

0.753

LOC509761

0.753

LOC527125

0.753

HYAL3

0.753

UGDH

0.746

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD44	HAS2	ENSBTAP00000048925	ENSBTAP00000026503	CD44 antigen.	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	0.842
CD44	HYAL1	ENSBTAP00000048925	ENSBTAP00000000611	CD44 antigen.	Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).	0.843
CD44	HYAL2	ENSBTAP00000048925	ENSBTAP00000000612	CD44 antigen.	Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family.	0.897
CD44	HYAL3	ENSBTAP00000048925	ENSBTAP00000071272	CD44 antigen.	Hyaluronidase.	0.799
CD44	HYAL4	ENSBTAP00000048925	ENSBTAP00000007294	CD44 antigen.	Hyaluronidase.	0.791
CD44	LOC509761	ENSBTAP00000048925	ENSBTAP00000042707	CD44 antigen.	Hyaluronidase.	0.786
CD44	LOC527125	ENSBTAP00000048925	ENSBTAP00000052425	CD44 antigen.	Hyaluronidase.	0.786
CD44	SPAM1	ENSBTAP00000048925	ENSBTAP00000006089	CD44 antigen.	Hyaluronidase.	0.796
CD44	TNFAIP6	ENSBTAP00000048925	ENSBTAP00000066584	CD44 antigen.	Tumor necrosis factor, alpha-induced protein 6.	0.822
HAS2	CD44	ENSBTAP00000026503	ENSBTAP00000048925	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	CD44 antigen.	0.842
HAS2	HYAL1	ENSBTAP00000026503	ENSBTAP00000000611	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).	0.873
HAS2	HYAL2	ENSBTAP00000026503	ENSBTAP00000000612	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity); Belongs to the glycosyl hydrolase 56 family.	0.869
HAS2	HYAL3	ENSBTAP00000026503	ENSBTAP00000071272	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase.	0.753
HAS2	HYAL4	ENSBTAP00000026503	ENSBTAP00000007294	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase.	0.755
HAS2	LOC509761	ENSBTAP00000026503	ENSBTAP00000042707	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase.	0.753
HAS2	LOC527125	ENSBTAP00000026503	ENSBTAP00000052425	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase.	0.753
HAS2	SPAM1	ENSBTAP00000026503	ENSBTAP00000006089	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Hyaluronidase.	0.753
HAS2	TNFAIP6	ENSBTAP00000026503	ENSBTAP00000066584	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	Tumor necrosis factor, alpha-induced protein 6.	0.841
HAS2	UGDH	ENSBTAP00000026503	ENSBTAP00000019302	Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...]	UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).	0.746
HYAL1	CD44	ENSBTAP00000000611	ENSBTAP00000048925	Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).	CD44 antigen.	0.843

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