STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC112443481Cathelicidin-4; Potent microbicidal activity; active against S.aureus and E.coli; Belongs to the cathelicidin family. (144 aa)    
Predicted Functional Partners:
NFKB1
Nuclear factor kappa B subunit 1.
   
 
 0.904
JUN
Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter; Belongs to the bZIP family. Jun subfamily.
     
 0.901
RELA
V-rel reticuloendotheliosis viral oncogene homolog A (Avian).
   
 
 0.901
CATHL4
Cathelicidin 4.
  
 
  
0.801
PRTN3
Proteinase 3; Belongs to the peptidase S1 family.
   
 
 0.785
BPIFA2A
Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
      
 0.741
KRTAP9-1
Uncharacterized protein.
      
 0.687
KRTAP9-2
Keratin associated protein 9-2.
      
 0.684
LAP
Lingual antimicrobial peptide; Shows a broad spectrum of antibacterial and antifungal activities; Belongs to the beta-defensin family. LAP/TAP subfamily.
   
  
 0.668
APOL3
APOL3 protein.
      
 0.665
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.