STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC112443481Cathelicidin-4; Potent microbicidal activity; active against S.aureus and E.coli; Belongs to the cathelicidin family. (144 aa)    
Predicted Functional Partners:
CATHL4
Cathelicidin 4.
  
 
  
0.801
PRTN3
Proteinase 3; Belongs to the peptidase S1 family.
     
 0.775
NGP
LOC788112 protein.
   
 
  0.739
ENSBTAP00000069791
Uncharacterized protein.
   
 
  0.739
BPIFA2A
Short palate, lung and nasal epithelium carcinoma-associated protein 2A; Belongs to the BPI/LBP/Plunc superfamily. Plunc family.
      
 0.680
PGLYRP1
Peptidoglycan recognition protein 1; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. Is microbicidal for Gram-positive and Gram-negative bacteria and yeast; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
   
  
 0.665
DEFB1
Beta-defensin 1; Has bactericidal activity. Active against E.coli ML35 but not against S.aureus 502A. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (By similarity); Belongs to the beta-defensin family.
   
  
 0.649
APOL3
APOL3 protein.
      
 0.638
APOL3-2
APOL3 protein.
      
 0.638
LAP
Lingual antimicrobial peptide; Shows a broad spectrum of antibacterial and antifungal activities; Belongs to the beta-defensin family. LAP/TAP subfamily.
   
  
 0.629
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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