node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GATA4 | GATA6 | ENSBTAP00000007134 | ENSBTAP00000007537 | GATA binding protein 4. | GATA binding protein 6. | 0.420 |
GATA4 | HAND2 | ENSBTAP00000007134 | ENSBTAP00000053239 | GATA binding protein 4. | Heart and neural crest derivatives expressed 2. | 0.905 |
GATA4 | MEF2A | ENSBTAP00000007134 | ENSBTAP00000073246 | GATA binding protein 4. | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] | 0.551 |
GATA4 | MEF2C | ENSBTAP00000007134 | ENSBTAP00000034894 | GATA binding protein 4. | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] | 0.907 |
GATA4 | NKX2-5 | ENSBTAP00000007134 | ENSBTAP00000027402 | GATA binding protein 4. | NK2 transcription factor related, locus 5 (Drosophila). | 0.966 |
GATA4 | NPPA | ENSBTAP00000007134 | ENSBTAP00000008819 | GATA binding protein 4. | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. | 0.799 |
GATA4 | TBX20 | ENSBTAP00000007134 | ENSBTAP00000023312 | GATA binding protein 4. | T-box transcription factor 20. | 0.888 |
GATA4 | TBX5 | ENSBTAP00000007134 | ENSBTAP00000015125 | GATA binding protein 4. | T-box transcription factor 5. | 0.931 |
GATA5 | GATA6 | ENSBTAP00000027184 | ENSBTAP00000007537 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | GATA binding protein 6. | 0.531 |
GATA5 | HAND2 | ENSBTAP00000027184 | ENSBTAP00000053239 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | Heart and neural crest derivatives expressed 2. | 0.624 |
GATA5 | MEF2C | ENSBTAP00000027184 | ENSBTAP00000034894 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] | 0.509 |
GATA5 | NKX2-5 | ENSBTAP00000027184 | ENSBTAP00000027402 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | NK2 transcription factor related, locus 5 (Drosophila). | 0.859 |
GATA5 | NPPA | ENSBTAP00000027184 | ENSBTAP00000008819 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity); Belongs to the natriuretic peptide family. | 0.462 |
GATA5 | TBX20 | ENSBTAP00000027184 | ENSBTAP00000023312 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | T-box transcription factor 20. | 0.732 |
GATA5 | TBX5 | ENSBTAP00000027184 | ENSBTAP00000015125 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | T-box transcription factor 5. | 0.709 |
GATA6 | GATA4 | ENSBTAP00000007537 | ENSBTAP00000007134 | GATA binding protein 6. | GATA binding protein 4. | 0.420 |
GATA6 | GATA5 | ENSBTAP00000007537 | ENSBTAP00000027184 | GATA binding protein 6. | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity). | 0.531 |
GATA6 | HAND2 | ENSBTAP00000007537 | ENSBTAP00000053239 | GATA binding protein 6. | Heart and neural crest derivatives expressed 2. | 0.686 |
GATA6 | MEF2A | ENSBTAP00000007537 | ENSBTAP00000073246 | GATA binding protein 6. | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] | 0.412 |
GATA6 | MEF2C | ENSBTAP00000007537 | ENSBTAP00000034894 | GATA binding protein 6. | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] | 0.614 |