node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTTNBP2NL | SETD6 | ENSBTAP00000072016 | ENSBTAP00000069257 | CTTNBP2 N-terminal like. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.520 |
GTF3C4 | KMT5B | ENSBTAP00000074328 | ENSBTAP00000070473 | General transcription factor IIIC subunit 4. | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | 0.532 |
GTF3C4 | SETD6 | ENSBTAP00000074328 | ENSBTAP00000069257 | General transcription factor IIIC subunit 4. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.497 |
KMT5B | GTF3C4 | ENSBTAP00000070473 | ENSBTAP00000074328 | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | General transcription factor IIIC subunit 4. | 0.532 |
KMT5B | SETD1B | ENSBTAP00000070473 | ENSBTAP00000022553 | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | SET domain containing 1B, histone lysine methyltransferase. | 0.428 |
KMT5B | SETD6 | ENSBTAP00000070473 | ENSBTAP00000069257 | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.582 |
NOB1 | SETD6 | ENSBTAP00000070112 | ENSBTAP00000069257 | RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity). | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.778 |
REL | RELA | ENSBTAP00000020447 | ENSBTAP00000018453 | REL proto-oncogene, NF-kB subunit. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.986 |
REL | RELB | ENSBTAP00000020447 | ENSBTAP00000049624 | REL proto-oncogene, NF-kB subunit. | RELB proto-oncogene, NF-kB subunit. | 0.985 |
REL | SETD6 | ENSBTAP00000020447 | ENSBTAP00000069257 | REL proto-oncogene, NF-kB subunit. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.528 |
RELA | REL | ENSBTAP00000018453 | ENSBTAP00000020447 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | REL proto-oncogene, NF-kB subunit. | 0.986 |
RELA | RELB | ENSBTAP00000018453 | ENSBTAP00000049624 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | RELB proto-oncogene, NF-kB subunit. | 0.999 |
RELA | SETD6 | ENSBTAP00000018453 | ENSBTAP00000069257 | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.930 |
RELB | REL | ENSBTAP00000049624 | ENSBTAP00000020447 | RELB proto-oncogene, NF-kB subunit. | REL proto-oncogene, NF-kB subunit. | 0.985 |
RELB | RELA | ENSBTAP00000049624 | ENSBTAP00000018453 | RELB proto-oncogene, NF-kB subunit. | V-rel reticuloendotheliosis viral oncogene homolog A (Avian). | 0.999 |
RELB | SETD6 | ENSBTAP00000049624 | ENSBTAP00000069257 | RELB proto-oncogene, NF-kB subunit. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.528 |
SETD1B | KMT5B | ENSBTAP00000022553 | ENSBTAP00000070473 | SET domain containing 1B, histone lysine methyltransferase. | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] | 0.428 |
SETD1B | SETD3 | ENSBTAP00000022553 | ENSBTAP00000024364 | SET domain containing 1B, histone lysine methyltransferase. | Protein-histidine N-methyltransferase. | 0.508 |
SETD1B | SETD4 | ENSBTAP00000022553 | ENSBTAP00000056973 | SET domain containing 1B, histone lysine methyltransferase. | SET domain containing 4. | 0.589 |
SETD1B | SETD6 | ENSBTAP00000022553 | ENSBTAP00000069257 | SET domain containing 1B, histone lysine methyltransferase. | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal (By similarity). | 0.547 |