node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | CASP1 | ENSBTAP00000069788 | ENSBTAP00000067605 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.772 |
APAF1 | CASP4 | ENSBTAP00000069788 | ENSBTAP00000027820 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | 0.752 |
APAF1 | CASP8 | ENSBTAP00000069788 | ENSBTAP00000062824 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.969 |
APAF1 | IL1B | ENSBTAP00000069788 | ENSBTAP00000001745 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.410 |
APAF1 | NAIP | ENSBTAP00000069788 | ENSBTAP00000004317 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | NLR family apoptosis inhibitory protein. | 0.528 |
CASP1 | APAF1 | ENSBTAP00000067605 | ENSBTAP00000069788 | Uncharacterized protein; Belongs to the peptidase C14A family. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.772 |
CASP1 | CASP4 | ENSBTAP00000067605 | ENSBTAP00000027820 | Uncharacterized protein; Belongs to the peptidase C14A family. | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | 0.856 |
CASP1 | CASP8 | ENSBTAP00000067605 | ENSBTAP00000062824 | Uncharacterized protein; Belongs to the peptidase C14A family. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.982 |
CASP1 | GSDMD | ENSBTAP00000067605 | ENSBTAP00000068320 | Uncharacterized protein; Belongs to the peptidase C14A family. | Gasdermin D. | 0.997 |
CASP1 | IL1B | ENSBTAP00000067605 | ENSBTAP00000001745 | Uncharacterized protein; Belongs to the peptidase C14A family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.996 |
CASP1 | NAIP | ENSBTAP00000067605 | ENSBTAP00000004317 | Uncharacterized protein; Belongs to the peptidase C14A family. | NLR family apoptosis inhibitory protein. | 0.892 |
CASP1 | NLRC4 | ENSBTAP00000067605 | ENSBTAP00000010814 | Uncharacterized protein; Belongs to the peptidase C14A family. | NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. | 0.999 |
CASP1 | NLRP1 | ENSBTAP00000067605 | ENSBTAP00000027232 | Uncharacterized protein; Belongs to the peptidase C14A family. | NLR family pyrin domain containing 1. | 0.987 |
CASP1 | NLRP3 | ENSBTAP00000067605 | ENSBTAP00000001675 | Uncharacterized protein; Belongs to the peptidase C14A family. | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] | 0.999 |
CASP1 | PYCARD | ENSBTAP00000067605 | ENSBTAP00000027359 | Uncharacterized protein; Belongs to the peptidase C14A family. | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8- dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase- 9, -2 and -3. Involved in macrophage pyroptosis, a cas [...] | 0.999 |
CASP4 | APAF1 | ENSBTAP00000027820 | ENSBTAP00000069788 | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.752 |
CASP4 | CASP1 | ENSBTAP00000027820 | ENSBTAP00000067605 | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | Uncharacterized protein; Belongs to the peptidase C14A family. | 0.856 |
CASP4 | CASP8 | ENSBTAP00000027820 | ENSBTAP00000062824 | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.825 |
CASP4 | GSDMD | ENSBTAP00000027820 | ENSBTAP00000068320 | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | Gasdermin D. | 0.989 |
CASP4 | IL1B | ENSBTAP00000027820 | ENSBTAP00000001745 | Caspase-4 subunit 1; Inflammatory caspase. Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, cholera enterotoxin subunit B and cytosolic LPS. Independently of NLRP3 inflammasome and CASP1, promotes pyroptosis, through GSDMD cleavage and activation, and IL1A, IL18 and HMGB1 release in response to non- canonical inflammasome activators. Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection. In later stages of th [...] | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.817 |