HIF1A protein (Bos taurus) - STRING interaction network

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HIF1A

Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...] (823 aa)

Predicted Functional Partners:

CREBBP

0.999

ARNT

0.999

EP300

0.998

HIF1AN

0.996

ARNT2

0.996

CUL2

0.992

ELOC

0.991

VHL

0.989

EGLN1

0.988

EGLN3

0.987

Your Current Organism:

Bos taurus

NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNT	ARNT2	ENSBTAP00000060357	ENSBTAP00000016391	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	Uncharacterized protein.	0.902
ARNT	CREBBP	ENSBTAP00000060357	ENSBTAP00000005092	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	CREB binding protein.	0.906
ARNT	CUL2	ENSBTAP00000060357	ENSBTAP00000070862	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	CUL2 protein; Belongs to the cullin family.	0.435
ARNT	EP300	ENSBTAP00000060357	ENSBTAP00000021556	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	E1A binding protein p300.	0.903
ARNT	HIF1A	ENSBTAP00000060357	ENSBTAP00000027885	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...]	0.999
ARNT2	ARNT	ENSBTAP00000016391	ENSBTAP00000060357	Uncharacterized protein.	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	0.902
ARNT2	CREBBP	ENSBTAP00000016391	ENSBTAP00000005092	Uncharacterized protein.	CREB binding protein.	0.451
ARNT2	CUL2	ENSBTAP00000016391	ENSBTAP00000070862	Uncharacterized protein.	CUL2 protein; Belongs to the cullin family.	0.595
ARNT2	EGLN3	ENSBTAP00000016391	ENSBTAP00000010744	Uncharacterized protein.	Egl-9 family hypoxia inducible factor 3.	0.562
ARNT2	ELOC	ENSBTAP00000016391	ENSBTAP00000065112	Uncharacterized protein.	Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an [...]	0.563
ARNT2	EP300	ENSBTAP00000016391	ENSBTAP00000021556	Uncharacterized protein.	E1A binding protein p300.	0.439
ARNT2	HIF1A	ENSBTAP00000016391	ENSBTAP00000027885	Uncharacterized protein.	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...]	0.996
CREBBP	ARNT	ENSBTAP00000005092	ENSBTAP00000060357	CREB binding protein.	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	0.906
CREBBP	ARNT2	ENSBTAP00000005092	ENSBTAP00000016391	CREB binding protein.	Uncharacterized protein.	0.451
CREBBP	EP300	ENSBTAP00000005092	ENSBTAP00000021556	CREB binding protein.	E1A binding protein p300.	0.997
CREBBP	HIF1A	ENSBTAP00000005092	ENSBTAP00000027885	CREB binding protein.	Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...]	0.999
CREBBP	HIF1AN	ENSBTAP00000005092	ENSBTAP00000000101	CREB binding protein.	Hypoxia inducible factor 1 subunit alpha inhibitor.	0.525
CREBBP	VHL	ENSBTAP00000005092	ENSBTAP00000030774	CREB binding protein.	Uncharacterized protein.	0.426
CUL2	ARNT	ENSBTAP00000070862	ENSBTAP00000060357	CUL2 protein; Belongs to the cullin family.	Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and funct [...]	0.435
CUL2	ARNT2	ENSBTAP00000070862	ENSBTAP00000016391	CUL2 protein; Belongs to the cullin family.	Uncharacterized protein.	0.595

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