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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY1Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis. (319 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.793
GRB2
Growth factor receptor-bound protein 2.
    
 
 0.654
SPRY2
Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
  
0.619
EGFR
Receptor protein-tyrosine kinase.
     
 0.613
ETV5
ETS variant 5.
      
 0.593
FGF8
Fibroblast growth factor; Belongs to the heparin-binding growth factors family.
      
 0.555
PDCD4
Programmed cell death 4.
      
 0.543
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 
 0.537
AREG
Amphiregulin.
     
 0.531
HBEGF
Heparin binding EGF like growth factor.
     
 0.531
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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