node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPIFB3 | TEX261 | ENSBTAP00000022985 | ENSBTAP00000071986 | BPI fold containing family B member 3. | Protein TEX261. | 0.741 |
BPIFB3 | TM4SF20 | ENSBTAP00000022985 | ENSBTAP00000028426 | BPI fold containing family B member 3. | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | 0.653 |
BPIFB3 | TTC16 | ENSBTAP00000022985 | ENSBTAP00000040770 | BPI fold containing family B member 3. | Tetratricopeptide repeat domain 16. | 0.690 |
CEACAM18 | TM4SF20 | ENSBTAP00000006050 | ENSBTAP00000028426 | Ig-like domain-containing protein. | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | 0.622 |
DEFB129 | TM4SF20 | ENSBTAP00000054689 | ENSBTAP00000028426 | Defensin beta 129. | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | 0.633 |
DEFB129 | TMBIM4 | ENSBTAP00000054689 | ENSBTAP00000008243 | Defensin beta 129. | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family. | 0.687 |
PLLP | TM4SF20 | ENSBTAP00000049090 | ENSBTAP00000028426 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | 0.633 |
PLLP | TM4SF4 | ENSBTAP00000049090 | ENSBTAP00000002463 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | Transmembrane 4 L six family member 4. | 0.536 |
TEX261 | BPIFB3 | ENSBTAP00000071986 | ENSBTAP00000022985 | Protein TEX261. | BPI fold containing family B member 3. | 0.741 |
TEX261 | TM4SF20 | ENSBTAP00000071986 | ENSBTAP00000028426 | Protein TEX261. | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | 0.740 |
TEX261 | TTC16 | ENSBTAP00000071986 | ENSBTAP00000040770 | Protein TEX261. | Tetratricopeptide repeat domain 16. | 0.786 |
TM4SF18 | TM4SF20 | ENSBTAP00000062224 | ENSBTAP00000028426 | Transmembrane 4 L6 family member 18. | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | 0.688 |
TM4SF20 | BPIFB3 | ENSBTAP00000028426 | ENSBTAP00000022985 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | BPI fold containing family B member 3. | 0.653 |
TM4SF20 | CEACAM18 | ENSBTAP00000028426 | ENSBTAP00000006050 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Ig-like domain-containing protein. | 0.622 |
TM4SF20 | DEFB129 | ENSBTAP00000028426 | ENSBTAP00000054689 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Defensin beta 129. | 0.633 |
TM4SF20 | PLLP | ENSBTAP00000028426 | ENSBTAP00000049090 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity). | 0.633 |
TM4SF20 | TEX261 | ENSBTAP00000028426 | ENSBTAP00000071986 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Protein TEX261. | 0.740 |
TM4SF20 | TM4SF18 | ENSBTAP00000028426 | ENSBTAP00000062224 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Transmembrane 4 L6 family member 18. | 0.688 |
TM4SF20 | TM4SF4 | ENSBTAP00000028426 | ENSBTAP00000002463 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Transmembrane 4 L six family member 4. | 0.853 |
TM4SF20 | TM4SF5 | ENSBTAP00000028426 | ENSBTAP00000062342 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. | Transmembrane 4 L6 family member 5; Acts as a lysosomal membrane arginine sensor (By similarity). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (By similarity). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (By similarity). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (By similarity). | 0.664 |