| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CA5A | GTF2H5 | ENSBTAP00000061809 | ENSBTAP00000058777 | Carbonic anhydrase 5A; Belongs to the alpha-carbonic anhydrase family. | General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.592 |
| CA5A | RPRM | ENSBTAP00000061809 | ENSBTAP00000028688 | Carbonic anhydrase 5A; Belongs to the alpha-carbonic anhydrase family. | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | 0.537 |
| CD164L2 | RPRM | ENSBTAP00000040689 | ENSBTAP00000028688 | CD164 molecule like 2. | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | 0.531 |
| DCAF13 | PAK1IP1 | ENSBTAP00000028594 | ENSBTAP00000024854 | DDB1 and CUL4 associated factor 13. | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | 0.882 |
| DCAF13 | RPRM | ENSBTAP00000028594 | ENSBTAP00000028688 | DDB1 and CUL4 associated factor 13. | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | 0.592 |
| DCAF13 | TMEM74 | ENSBTAP00000028594 | ENSBTAP00000047585 | DDB1 and CUL4 associated factor 13. | Transmembrane protein 74. | 0.640 |
| DCAF13 | WDR20 | ENSBTAP00000028594 | ENSBTAP00000056668 | DDB1 and CUL4 associated factor 13. | WD repeat domain 20. | 0.738 |
| GTF2H5 | CA5A | ENSBTAP00000058777 | ENSBTAP00000061809 | General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | Carbonic anhydrase 5A; Belongs to the alpha-carbonic anhydrase family. | 0.592 |
| GTF2H5 | RPRM | ENSBTAP00000058777 | ENSBTAP00000028688 | General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | 0.560 |
| LOC112441461 | RPRM | ENSBTAP00000057547 | ENSBTAP00000028688 | UPAR/Ly6 domain-containing protein. | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | 0.665 |
| PAK1IP1 | DCAF13 | ENSBTAP00000024854 | ENSBTAP00000028594 | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | DDB1 and CUL4 associated factor 13. | 0.882 |
| PAK1IP1 | RPRM | ENSBTAP00000024854 | ENSBTAP00000028688 | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | 0.607 |
| PAK1IP1 | TMEM74 | ENSBTAP00000024854 | ENSBTAP00000047585 | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | Transmembrane protein 74. | 0.652 |
| PAK1IP1 | WDR20 | ENSBTAP00000024854 | ENSBTAP00000056668 | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | WD repeat domain 20. | 0.748 |
| RPRM | CA5A | ENSBTAP00000028688 | ENSBTAP00000061809 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | Carbonic anhydrase 5A; Belongs to the alpha-carbonic anhydrase family. | 0.537 |
| RPRM | CD164L2 | ENSBTAP00000028688 | ENSBTAP00000040689 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | CD164 molecule like 2. | 0.531 |
| RPRM | DCAF13 | ENSBTAP00000028688 | ENSBTAP00000028594 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | DDB1 and CUL4 associated factor 13. | 0.592 |
| RPRM | GTF2H5 | ENSBTAP00000028688 | ENSBTAP00000058777 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.560 |
| RPRM | LOC112441461 | ENSBTAP00000028688 | ENSBTAP00000057547 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | UPAR/Ly6 domain-containing protein. | 0.665 |
| RPRM | PAK1IP1 | ENSBTAP00000028688 | ENSBTAP00000024854 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity); Belongs to the reprimo family. | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. | 0.607 |