Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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TMEM65Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication (By similarity). Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity). (236 aa)    
Predicted Functional Partners:
ADM5
Uncharacterized protein.
      
 0.681
ACAA2
3-ketoacyl-CoA thiolase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.
    
 
 0.676
TAX1BP3
Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
    
   0.636
ZSWIM4
Zinc finger SWIM-type containing 4.
      
 0.614
FAM162A
Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus (By similarity).
   
  
 0.544
PLEKHA8
Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...]
   
  
 0.543
TMEM225B
LOC513111 protein.
      
 0.535
CETN3
Centrin 3.
   
  
 0.528
RASEF
RAS and EF-hand domain containing.
      
 0.516
FOXR1
Forkhead box R1.
      
 0.509
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
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