node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | FGF4 | ENSBTAP00000070620 | ENSBTAP00000029936 | Receptor protein-tyrosine kinase. | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | 0.876 |
EGFR | FGFR1 | ENSBTAP00000070620 | ENSBTAP00000058842 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.451 |
EGFR | FGFR2 | ENSBTAP00000070620 | ENSBTAP00000059738 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.632 |
EGFR | FGFR3 | ENSBTAP00000070620 | ENSBTAP00000073540 | Receptor protein-tyrosine kinase. | Fibroblast growth factor receptor. | 0.631 |
EGFR | HGF | ENSBTAP00000070620 | ENSBTAP00000023490 | Receptor protein-tyrosine kinase. | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.946 |
EGFR | IGF1 | ENSBTAP00000070620 | ENSBTAP00000055243 | Receptor protein-tyrosine kinase. | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.975 |
EGFR | KDR | ENSBTAP00000070620 | ENSBTAP00000001038 | Receptor protein-tyrosine kinase. | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.660 |
EGFR | PDGFRA | ENSBTAP00000070620 | ENSBTAP00000068814 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.967 |
EGFR | PDGFRB | ENSBTAP00000070620 | ENSBTAP00000064374 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.977 |
FGF4 | EGFR | ENSBTAP00000029936 | ENSBTAP00000070620 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Receptor protein-tyrosine kinase. | 0.876 |
FGF4 | FGFR1 | ENSBTAP00000029936 | ENSBTAP00000058842 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Fibroblast growth factor receptor. | 0.995 |
FGF4 | FGFR2 | ENSBTAP00000029936 | ENSBTAP00000059738 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Fibroblast growth factor receptor. | 0.990 |
FGF4 | FGFR3 | ENSBTAP00000029936 | ENSBTAP00000073540 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Fibroblast growth factor receptor. | 0.951 |
FGF4 | FGFR4 | ENSBTAP00000029936 | ENSBTAP00000013942 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Fibroblast growth factor receptor. | 0.961 |
FGF4 | HGF | ENSBTAP00000029936 | ENSBTAP00000023490 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization (By similarity); Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.854 |
FGF4 | IGF1 | ENSBTAP00000029936 | ENSBTAP00000055243 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] | 0.864 |
FGF4 | KDR | ENSBTAP00000029936 | ENSBTAP00000001038 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. | 0.847 |
FGF4 | PDGFRA | ENSBTAP00000029936 | ENSBTAP00000068814 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.886 |
FGF4 | PDGFRB | ENSBTAP00000029936 | ENSBTAP00000064374 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis (By similarity). | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.858 |
FGFR1 | EGFR | ENSBTAP00000058842 | ENSBTAP00000070620 | Fibroblast growth factor receptor. | Receptor protein-tyrosine kinase. | 0.451 |