node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC88B | GPR137 | ENSBTAP00000064150 | ENSBTAP00000064905 | Coiled-coil domain containing 88B. | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | 0.792 |
CCDC88B | KCNK4 | ENSBTAP00000064150 | ENSBTAP00000011399 | Coiled-coil domain containing 88B. | Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.774 |
CCDC88B | MEX3C | ENSBTAP00000064150 | ENSBTAP00000019818 | Coiled-coil domain containing 88B. | Mex-3 RNA binding family member C. | 0.723 |
CCDC88B | TRMT112 | ENSBTAP00000064150 | ENSBTAP00000011401 | Coiled-coil domain containing 88B. | Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S- adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading t [...] | 0.686 |
CCDC88B | ZNF572 | ENSBTAP00000064150 | ENSBTAP00000063339 | Coiled-coil domain containing 88B. | Zinc finger protein 572; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.550 |
DXO | GPR137 | ENSBTAP00000007340 | ENSBTAP00000064905 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | 0.598 |
DXO | GTF2H2 | ENSBTAP00000007340 | ENSBTAP00000061028 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.558 |
GPR135 | GPR137 | ENSBTAP00000005938 | ENSBTAP00000064905 | G protein-coupled receptor 135; Belongs to the G-protein coupled receptor 1 family. | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | 0.748 |
GPR137 | CCDC88B | ENSBTAP00000064905 | ENSBTAP00000064150 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Coiled-coil domain containing 88B. | 0.792 |
GPR137 | DXO | ENSBTAP00000064905 | ENSBTAP00000007340 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | 0.598 |
GPR137 | GPR135 | ENSBTAP00000064905 | ENSBTAP00000005938 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | G protein-coupled receptor 135; Belongs to the G-protein coupled receptor 1 family. | 0.748 |
GPR137 | GPR158 | ENSBTAP00000064905 | ENSBTAP00000032818 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | 0.579 |
GPR137 | GTF2H2 | ENSBTAP00000064905 | ENSBTAP00000061028 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | 0.569 |
GPR137 | KCNK4 | ENSBTAP00000064905 | ENSBTAP00000011399 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | 0.807 |
GPR137 | MEX3C | ENSBTAP00000064905 | ENSBTAP00000019818 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Mex-3 RNA binding family member C. | 0.746 |
GPR137 | SPATA19 | ENSBTAP00000064905 | ENSBTAP00000019506 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis. | 0.564 |
GPR137 | TRMT112 | ENSBTAP00000064905 | ENSBTAP00000011401 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S- adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Involved in the pre-rRNA processing steps leading t [...] | 0.691 |
GPR137 | ZNF572 | ENSBTAP00000064905 | ENSBTAP00000063339 | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | Zinc finger protein 572; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.573 |
GPR158 | GPR137 | ENSBTAP00000032818 | ENSBTAP00000064905 | Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. | Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy. | 0.579 |
GTF2H2 | DXO | ENSBTAP00000061028 | ENSBTAP00000007340 | General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by [...] | 0.558 |