node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DOCK1 | DOCK2 | ENSBTAP00000032659 | ENSBTAP00000059976 | Dedicator of cytokinesis 1; Belongs to the DOCK family. | Dedicator of cytokinesis 2; Belongs to the DOCK family. | 0.426 |
DOCK1 | ELMO1 | ENSBTAP00000032659 | ENSBTAP00000070261 | Dedicator of cytokinesis 1; Belongs to the DOCK family. | Engulfment and cell motility 1. | 0.988 |
DOCK1 | RAC3 | ENSBTAP00000032659 | ENSBTAP00000067666 | Dedicator of cytokinesis 1; Belongs to the DOCK family. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.966 |
DOCK1 | TIAM1 | ENSBTAP00000032659 | ENSBTAP00000023716 | Dedicator of cytokinesis 1; Belongs to the DOCK family. | DH domain-containing protein. | 0.540 |
DOCK1 | VAV2 | ENSBTAP00000032659 | ENSBTAP00000073942 | Dedicator of cytokinesis 1; Belongs to the DOCK family. | Vav guanine nucleotide exchange factor 2. | 0.615 |
DOCK1 | WASL | ENSBTAP00000032659 | ENSBTAP00000006094 | Dedicator of cytokinesis 1; Belongs to the DOCK family. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.694 |
DOCK2 | DOCK1 | ENSBTAP00000059976 | ENSBTAP00000032659 | Dedicator of cytokinesis 2; Belongs to the DOCK family. | Dedicator of cytokinesis 1; Belongs to the DOCK family. | 0.426 |
DOCK2 | ELMO1 | ENSBTAP00000059976 | ENSBTAP00000070261 | Dedicator of cytokinesis 2; Belongs to the DOCK family. | Engulfment and cell motility 1. | 0.995 |
DOCK2 | RAC3 | ENSBTAP00000059976 | ENSBTAP00000067666 | Dedicator of cytokinesis 2; Belongs to the DOCK family. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.967 |
DOCK2 | VAV1 | ENSBTAP00000059976 | ENSBTAP00000050922 | Dedicator of cytokinesis 2; Belongs to the DOCK family. | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.739 |
DOCK2 | VAV2 | ENSBTAP00000059976 | ENSBTAP00000073942 | Dedicator of cytokinesis 2; Belongs to the DOCK family. | Vav guanine nucleotide exchange factor 2. | 0.558 |
ELMO1 | DOCK1 | ENSBTAP00000070261 | ENSBTAP00000032659 | Engulfment and cell motility 1. | Dedicator of cytokinesis 1; Belongs to the DOCK family. | 0.988 |
ELMO1 | DOCK2 | ENSBTAP00000070261 | ENSBTAP00000059976 | Engulfment and cell motility 1. | Dedicator of cytokinesis 2; Belongs to the DOCK family. | 0.995 |
ELMO1 | RAC3 | ENSBTAP00000070261 | ENSBTAP00000067666 | Engulfment and cell motility 1. | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.964 |
PAK1 | PAK3 | ENSBTAP00000013448 | ENSBTAP00000060136 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | P21 (RAC1) activated kinase 3. | 0.902 |
PAK1 | RAC3 | ENSBTAP00000013448 | ENSBTAP00000067666 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...] | 0.982 |
PAK1 | TIAM1 | ENSBTAP00000013448 | ENSBTAP00000023716 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | DH domain-containing protein. | 0.970 |
PAK1 | VAV1 | ENSBTAP00000013448 | ENSBTAP00000050922 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.669 |
PAK1 | VAV2 | ENSBTAP00000013448 | ENSBTAP00000073942 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | Vav guanine nucleotide exchange factor 2. | 0.739 |
PAK1 | WASL | ENSBTAP00000013448 | ENSBTAP00000006094 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.753 |