node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AZU1 | BPI | ENSBTAP00000056087 | ENSBTAP00000018669 | Azurocidin 1. | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | 0.657 |
AZU1 | LOC505658 | ENSBTAP00000056087 | ENSBTAP00000052108 | Azurocidin 1. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.626 |
AZU1 | LOC785803 | ENSBTAP00000056087 | ENSBTAP00000031167 | Azurocidin 1. | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | 0.624 |
AZU1 | LTF | ENSBTAP00000056087 | ENSBTAP00000001704 | Azurocidin 1. | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria. | 0.685 |
AZU1 | MPO | ENSBTAP00000056087 | ENSBTAP00000070439 | Azurocidin 1. | Myeloperoxidase. | 0.793 |
AZU1 | S100A9 | ENSBTAP00000056087 | ENSBTAP00000067294 | Azurocidin 1. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.561 |
BPI | AZU1 | ENSBTAP00000018669 | ENSBTAP00000056087 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | Azurocidin 1. | 0.657 |
BPI | LOC505658 | ENSBTAP00000018669 | ENSBTAP00000052108 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.785 |
BPI | LOC785803 | ENSBTAP00000018669 | ENSBTAP00000031167 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | 0.615 |
BPI | LTF | ENSBTAP00000018669 | ENSBTAP00000001704 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria. | 0.804 |
BPI | MPO | ENSBTAP00000018669 | ENSBTAP00000070439 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | Myeloperoxidase. | 0.802 |
BPI | S100A9 | ENSBTAP00000018669 | ENSBTAP00000067294 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] | 0.430 |
KCNK5 | LOC785803 | ENSBTAP00000014756 | ENSBTAP00000031167 | Potassium two pore domain channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | 0.532 |
KCNK5 | SCNN1D | ENSBTAP00000014756 | ENSBTAP00000023511 | Potassium two pore domain channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. | Sodium channel epithelial 1 delta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. | 0.535 |
LOC505658 | AZU1 | ENSBTAP00000052108 | ENSBTAP00000056087 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Azurocidin 1. | 0.626 |
LOC505658 | BPI | ENSBTAP00000052108 | ENSBTAP00000018669 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. | 0.785 |
LOC505658 | LOC785803 | ENSBTAP00000052108 | ENSBTAP00000031167 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | 0.747 |
LOC505658 | LTF | ENSBTAP00000052108 | ENSBTAP00000001704 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria. | 0.974 |
LOC505658 | MPO | ENSBTAP00000052108 | ENSBTAP00000070439 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Myeloperoxidase. | 0.995 |
LOC785803 | AZU1 | ENSBTAP00000031167 | ENSBTAP00000056087 | Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family. | Azurocidin 1. | 0.624 |