node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAA1 | ACADL | ENSBTAP00000024335 | ENSBTAP00000013988 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acyl-Coenzyme A dehydrogenase, long chain. | 0.975 |
ACAA1 | ACADM | ENSBTAP00000024335 | ENSBTAP00000033383 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). | 0.980 |
ACAA1 | ACADVL | ENSBTAP00000024335 | ENSBTAP00000003999 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family. | 0.976 |
ACAA1 | ACAT1 | ENSBTAP00000024335 | ENSBTAP00000017122 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | 0.955 |
ACAA1 | ACOX1 | ENSBTAP00000024335 | ENSBTAP00000070369 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. | 0.995 |
ACAA1 | ACOX3 | ENSBTAP00000024335 | ENSBTAP00000041634 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.980 |
ACAA1 | CPT2 | ENSBTAP00000024335 | ENSBTAP00000019505 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. | 0.783 |
ACAA1 | EHHADH | ENSBTAP00000024335 | ENSBTAP00000053200 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. | 0.996 |
ACAA1 | ETFA | ENSBTAP00000024335 | ENSBTAP00000016570 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.681 |
ACAA1 | HADHB | ENSBTAP00000024335 | ENSBTAP00000070545 | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.948 |
ACADL | ACAA1 | ENSBTAP00000013988 | ENSBTAP00000024335 | Acyl-Coenzyme A dehydrogenase, long chain. | Mitochondrial acetyl-Coenzyme A acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.975 |
ACADL | ACADM | ENSBTAP00000013988 | ENSBTAP00000033383 | Acyl-Coenzyme A dehydrogenase, long chain. | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). | 0.967 |
ACADL | ACADVL | ENSBTAP00000013988 | ENSBTAP00000003999 | Acyl-Coenzyme A dehydrogenase, long chain. | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons; Belongs to the acyl-CoA dehydrogenase family. | 0.949 |
ACADL | ACAT1 | ENSBTAP00000013988 | ENSBTAP00000017122 | Acyl-Coenzyme A dehydrogenase, long chain. | Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] | 0.629 |
ACADL | ACOX1 | ENSBTAP00000013988 | ENSBTAP00000070369 | Acyl-Coenzyme A dehydrogenase, long chain. | Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. | 0.976 |
ACADL | ACOX3 | ENSBTAP00000013988 | ENSBTAP00000041634 | Acyl-Coenzyme A dehydrogenase, long chain. | Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. | 0.946 |
ACADL | CPT2 | ENSBTAP00000013988 | ENSBTAP00000019505 | Acyl-Coenzyme A dehydrogenase, long chain. | Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family. | 0.979 |
ACADL | EHHADH | ENSBTAP00000013988 | ENSBTAP00000053200 | Acyl-Coenzyme A dehydrogenase, long chain. | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase. | 0.980 |
ACADL | ETFA | ENSBTAP00000013988 | ENSBTAP00000016570 | Acyl-Coenzyme A dehydrogenase, long chain. | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. | 0.884 |
ACADL | HADHB | ENSBTAP00000013988 | ENSBTAP00000070545 | Acyl-Coenzyme A dehydrogenase, long chain. | Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] | 0.987 |