node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APP | LOC100848132 | ENSBTAP00000060984 | ENSBTAP00000065010 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.983 |
APP | LOC780933 | ENSBTAP00000060984 | ENSBTAP00000004737 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Alpha-trypsin chain 1. | 0.939 |
APP | PRSS1 | ENSBTAP00000060984 | ENSBTAP00000033392 | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | Protease, serine, 1 (trypsin 1). | 0.927 |
CPA1 | LOC100848132 | ENSBTAP00000009745 | ENSBTAP00000065010 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.483 |
CPA1 | LOC780933 | ENSBTAP00000009745 | ENSBTAP00000004737 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family. | Alpha-trypsin chain 1. | 0.404 |
CPA1 | PRSS1 | ENSBTAP00000009745 | ENSBTAP00000033392 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family. | Protease, serine, 1 (trypsin 1). | 0.627 |
CPA1 | SPINK1 | ENSBTAP00000009745 | ENSBTAP00000020673 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. | 0.604 |
HGFAC | LOC780933 | ENSBTAP00000023055 | ENSBTAP00000004737 | HGF activator. | Alpha-trypsin chain 1. | 0.718 |
HGFAC | PRSS1 | ENSBTAP00000023055 | ENSBTAP00000033392 | HGF activator. | Protease, serine, 1 (trypsin 1). | 0.703 |
HGFAC | PTI | ENSBTAP00000023055 | ENSBTAP00000056883 | HGF activator. | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.437 |
HGFAC | SERPINA5 | ENSBTAP00000023055 | ENSBTAP00000005307 | HGF activator. | Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] | 0.446 |
HGFAC | SPINT2 | ENSBTAP00000023055 | ENSBTAP00000000207 | HGF activator. | Serine peptidase inhibitor, Kunitz type, 2. | 0.712 |
LOC100848132 | APP | ENSBTAP00000065010 | ENSBTAP00000060984 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.983 |
LOC100848132 | CPA1 | ENSBTAP00000065010 | ENSBTAP00000009745 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family. | 0.483 |
LOC100848132 | LOC780933 | ENSBTAP00000065010 | ENSBTAP00000004737 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Alpha-trypsin chain 1. | 0.934 |
LOC100848132 | PRSS1 | ENSBTAP00000065010 | ENSBTAP00000033392 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Protease, serine, 1 (trypsin 1). | 0.928 |
LOC100848132 | PTI | ENSBTAP00000065010 | ENSBTAP00000056883 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Pancreatic trypsin inhibitor; Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | 0.999 |
LOC100848132 | SPINK1 | ENSBTAP00000065010 | ENSBTAP00000020673 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. | 0.807 |
LOC100848132 | TFPI | ENSBTAP00000065010 | ENSBTAP00000073176 | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor. | 0.590 |
LOC780933 | APP | ENSBTAP00000004737 | ENSBTAP00000060984 | Alpha-trypsin chain 1. | Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] | 0.939 |