node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRK1 | HSBP1-2 | ENSBTAP00000021429 | ENSBTAP00000034543 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. | Heat shock factor binding protein 1. | 0.551 |
BRK1 | LAMTOR1 | ENSBTAP00000021429 | ENSBTAP00000059517 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.606 |
BRK1 | WASHC3 | ENSBTAP00000021429 | ENSBTAP00000000022 | BRICK1 subunit of SCAR/WAVE actin nucleating complex. | WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. | 0.783 |
EMP2 | HSBP1-2 | ENSBTAP00000009444 | ENSBTAP00000034543 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] | Heat shock factor binding protein 1. | 0.483 |
G3N2R1_BOVIN | HSBP1-2 | ENSBTAP00000056179 | ENSBTAP00000034543 | 60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. | Heat shock factor binding protein 1. | 0.692 |
HSBP1-2 | BRK1 | ENSBTAP00000034543 | ENSBTAP00000021429 | Heat shock factor binding protein 1. | BRICK1 subunit of SCAR/WAVE actin nucleating complex. | 0.551 |
HSBP1-2 | EMP2 | ENSBTAP00000034543 | ENSBTAP00000009444 | Heat shock factor binding protein 1. | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation. Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins. Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T- cell mediated cytotoxicity. R [...] | 0.483 |
HSBP1-2 | G3N2R1_BOVIN | ENSBTAP00000034543 | ENSBTAP00000056179 | Heat shock factor binding protein 1. | 60S ribosomal protein L6; Belongs to the eukaryotic ribosomal protein eL6 family. | 0.692 |
HSBP1-2 | HSF2 | ENSBTAP00000034543 | ENSBTAP00000059067 | Heat shock factor binding protein 1. | Heat shock transcription factor 2. | 0.492 |
HSBP1-2 | HSPH1 | ENSBTAP00000034543 | ENSBTAP00000006600 | Heat shock factor binding protein 1. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.551 |
HSBP1-2 | LAMTOR1 | ENSBTAP00000034543 | ENSBTAP00000059517 | Heat shock factor binding protein 1. | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] | 0.573 |
HSBP1-2 | PSMD4 | ENSBTAP00000034543 | ENSBTAP00000008019 | Heat shock factor binding protein 1. | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | 0.502 |
HSBP1-2 | SMS | ENSBTAP00000034543 | ENSBTAP00000071420 | Heat shock factor binding protein 1. | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM). | 0.615 |
HSBP1-2 | STOML2 | ENSBTAP00000034543 | ENSBTAP00000015136 | Heat shock factor binding protein 1. | Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. M [...] | 0.594 |
HSBP1-2 | WASHC3 | ENSBTAP00000034543 | ENSBTAP00000000022 | Heat shock factor binding protein 1. | WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. | 0.829 |
HSF2 | HSBP1-2 | ENSBTAP00000059067 | ENSBTAP00000034543 | Heat shock transcription factor 2. | Heat shock factor binding protein 1. | 0.492 |
HSF2 | HSPH1 | ENSBTAP00000059067 | ENSBTAP00000006600 | Heat shock transcription factor 2. | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | 0.595 |
HSPH1 | HSBP1-2 | ENSBTAP00000006600 | ENSBTAP00000034543 | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | Heat shock factor binding protein 1. | 0.551 |
HSPH1 | HSF2 | ENSBTAP00000006600 | ENSBTAP00000059067 | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | Heat shock transcription factor 2. | 0.595 |
HSPH1 | STOML2 | ENSBTAP00000006600 | ENSBTAP00000015136 | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering substrate release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities. | Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. M [...] | 0.413 |