node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOA1 | CD163 | ENSBTAP00000002914 | ENSBTAP00000026215 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | 0.465 |
APOA1 | HBA | ENSBTAP00000002914 | ENSBTAP00000037374 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | 0.806 |
APOA1 | HBB | ENSBTAP00000002914 | ENSBTAP00000050256 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.800 |
APOA1 | HBG | ENSBTAP00000002914 | ENSBTAP00000043063 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Hemoglobin fetal subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.429 |
APOA1 | HP | ENSBTAP00000002914 | ENSBTAP00000071329 | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] | 0.879 |
CD163 | APOA1 | ENSBTAP00000026215 | ENSBTAP00000002914 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.465 |
CD163 | HBA | ENSBTAP00000026215 | ENSBTAP00000037374 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | 0.783 |
CD163 | HBB | ENSBTAP00000026215 | ENSBTAP00000050256 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.828 |
CD163 | HP | ENSBTAP00000026215 | ENSBTAP00000071329 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] | 0.982 |
ENSBTAP00000068484 | HBA | ENSBTAP00000068484 | ENSBTAP00000037374 | GLOBIN domain-containing protein; Belongs to the globin family. | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | 0.767 |
ENSBTAP00000068484 | HBB | ENSBTAP00000068484 | ENSBTAP00000050256 | GLOBIN domain-containing protein; Belongs to the globin family. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.415 |
ENSBTAP00000068484 | HBG | ENSBTAP00000068484 | ENSBTAP00000043063 | GLOBIN domain-containing protein; Belongs to the globin family. | Hemoglobin fetal subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.416 |
ENSBTAP00000068484 | LOC107131172 | ENSBTAP00000068484 | ENSBTAP00000055887 | GLOBIN domain-containing protein; Belongs to the globin family. | GLOBIN domain-containing protein; Belongs to the globin family. | 0.416 |
ENSBTAP00000068484 | LOC787671 | ENSBTAP00000068484 | ENSBTAP00000073455 | GLOBIN domain-containing protein; Belongs to the globin family. | GLOBIN domain-containing protein; Belongs to the globin family. | 0.428 |
HBA | APOA1 | ENSBTAP00000037374 | ENSBTAP00000002914 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. | 0.806 |
HBA | CD163 | ENSBTAP00000037374 | ENSBTAP00000026215 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] | 0.783 |
HBA | ENSBTAP00000068484 | ENSBTAP00000037374 | ENSBTAP00000068484 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | GLOBIN domain-containing protein; Belongs to the globin family. | 0.767 |
HBA | HBB | ENSBTAP00000037374 | ENSBTAP00000050256 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. | 0.999 |
HBA | HBE1 | ENSBTAP00000037374 | ENSBTAP00000049033 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | GLOBIN domain-containing protein; Belongs to the globin family. | 0.817 |
HBA | HBE1-2 | ENSBTAP00000037374 | ENSBTAP00000052532 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. | GLOBIN domain-containing protein; Belongs to the globin family. | 0.816 |