STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UBE3DE3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. (400 aa)    
Predicted Functional Partners:
RBBP6
RB binding protein 6, ubiquitin ligase.
    
 
 0.959
CPSF3
Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'- end-processing endonuclease. Also involved in the histone 3'-end pre- mRNA processing. U7 snRNP-dependent protein that induces both the 3'- endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' [...]
   
 
 0.769
ARIH2
RBR-type E3 ubiquitin transferase.
      
 0.718
ZNF668
Zinc finger protein 668; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family.
      
 0.688
ZNF787
Zinc finger protein 787.
      
 0.651
MRPS30
28S ribosomal protein S30, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL65 family.
   
  
 0.635
C14H8orf34
Chromosome 14 C8orf34 homolog.
      
 0.627
LRSAM1
Leucine rich repeat and sterile alpha motif containing 1.
      
 0.570
RTP1
Receptor transporter protein 1.
      
 0.568
TRIM63
Tripartite motif containing 63.
      
 0.537
Your Current Organism:
Bos taurus
NCBI taxonomy Id: 9913
Other names: B. taurus, Bos bovis, Bos primigenius taurus, Bovidae sp. Adi Nefas, bovine, cattle, cow, dairy cow, domestic cattle, domestic cow
Server load: low (10%) [HD]